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Dilation-Responsive Microshape Programing Prevents Vascular Graft Stenosis

Authors
 Se Won Yi  ;  Young Min Shin  ;  Jung Bok Lee  ;  Ju Young Park  ;  Dae-Hyun Kim  ;  Wooyeol Baek  ;  Jeong-Kee Yoon  ;  Deok Gie Kim  ;  In Sik Shin  ;  Chang-Soo Kim  ;  Mi-Lan Kang  ;  Jae Won Yang  ;  Hak-Joon Sung 
Citation
 SMALL, Vol.17(18) : e2007297, 2021-05 
Journal Title
SMALL
ISSN
 1613-6810 
Issue Date
2021-05
MeSH
Constriction, Pathologic ; Dilatation ; Humans ; Vasa Vasorum* ; Vascular Diseases* / prevention & control ; Veins
Keywords
dilation-responsive ; microscale shape programming ; self-enclosable external support ; shape-fixity ; vein-to-artery grafting
Abstract
Shape memory materials have been successfully applied to minimally invasive implantation of medical devices. However, organ-movement-specific shape programing at a microscale level has never been demonstrated despite significant unmet needs. As vein-to-artery grafting induces vein dilation and stenosis, a polymeric self-enclosable external support (SES) is designed to wrap the vascular out-wall. Its micropores are programmed to increase sizes and interconnections upon dilation. Vessel dilation promotes venous maturation, but overdilation induces stenosis by disturbed blood flow. Therefore, the unique elastic shape-fixity of SES provides a foundation to enable a stable microscale shape transition by maintaining the vein dilation. The shape transition of micropore architecture upon dilation induces beneficial inflammation, thereby regenerating vasa vasorum and directing smooth muscle cell migration toward adventitia with the consequent muscle reinforcement of veins. This game-changer approach prevents the stenosis of vein-to-artery grafting by rescuing ischemic disorders and promoting arterial properties of veins.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/smll.202007297
DOI
10.1002/smll.202007297
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Mi-Lan(강미란)
Baek, Wooyeol(백우열) ORCID logo https://orcid.org/0000-0002-6638-4110
Sung, Hak-Joon(성학준) ORCID logo https://orcid.org/0000-0003-2312-2484
Shin, Young Min(신영민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184063
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