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Dilation-Responsive Microshape Programing Prevents Vascular Graft Stenosis

DC Field Value Language
dc.contributor.author강미란-
dc.contributor.author백우열-
dc.contributor.author성학준-
dc.contributor.author신영민-
dc.date.accessioned2021-09-29T00:50:35Z-
dc.date.available2021-09-29T00:50:35Z-
dc.date.issued2021-05-
dc.identifier.issn1613-6810-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184063-
dc.description.abstractShape memory materials have been successfully applied to minimally invasive implantation of medical devices. However, organ-movement-specific shape programing at a microscale level has never been demonstrated despite significant unmet needs. As vein-to-artery grafting induces vein dilation and stenosis, a polymeric self-enclosable external support (SES) is designed to wrap the vascular out-wall. Its micropores are programmed to increase sizes and interconnections upon dilation. Vessel dilation promotes venous maturation, but overdilation induces stenosis by disturbed blood flow. Therefore, the unique elastic shape-fixity of SES provides a foundation to enable a stable microscale shape transition by maintaining the vein dilation. The shape transition of micropore architecture upon dilation induces beneficial inflammation, thereby regenerating vasa vasorum and directing smooth muscle cell migration toward adventitia with the consequent muscle reinforcement of veins. This game-changer approach prevents the stenosis of vein-to-artery grafting by rescuing ischemic disorders and promoting arterial properties of veins.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-VCH-
dc.relation.isPartOfSMALL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHConstriction, Pathologic-
dc.subject.MESHDilatation-
dc.subject.MESHHumans-
dc.subject.MESHVasa Vasorum*-
dc.subject.MESHVascular Diseases* / prevention & control-
dc.subject.MESHVeins-
dc.titleDilation-Responsive Microshape Programing Prevents Vascular Graft Stenosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorSe Won Yi-
dc.contributor.googleauthorYoung Min Shin-
dc.contributor.googleauthorJung Bok Lee-
dc.contributor.googleauthorJu Young Park-
dc.contributor.googleauthorDae-Hyun Kim-
dc.contributor.googleauthorWooyeol Baek-
dc.contributor.googleauthorJeong-Kee Yoon-
dc.contributor.googleauthorDeok Gie Kim-
dc.contributor.googleauthorIn Sik Shin-
dc.contributor.googleauthorChang-Soo Kim-
dc.contributor.googleauthorMi-Lan Kang-
dc.contributor.googleauthorJae Won Yang-
dc.contributor.googleauthorHak-Joon Sung-
dc.identifier.doi10.1002/smll.202007297-
dc.contributor.localIdA05812-
dc.contributor.localIdA04949-
dc.contributor.localIdA01958-
dc.contributor.localIdA05925-
dc.relation.journalcodeJ02664-
dc.identifier.eissn1613-6829-
dc.identifier.pmid33729684-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1002/smll.202007297-
dc.subject.keyworddilation-responsive-
dc.subject.keywordmicroscale shape programming-
dc.subject.keywordself-enclosable external support-
dc.subject.keywordshape-fixity-
dc.subject.keywordvein-to-artery grafting-
dc.contributor.alternativeNameKang, Mi-Lan-
dc.contributor.affiliatedAuthor강미란-
dc.contributor.affiliatedAuthor백우열-
dc.contributor.affiliatedAuthor성학준-
dc.contributor.affiliatedAuthor신영민-
dc.citation.volume17-
dc.citation.number18-
dc.citation.startPagee2007297-
dc.identifier.bibliographicCitationSMALL, Vol.17(18) : e2007297, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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