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Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer's disease

Authors
 Min Seok Baek  ;  Hanna Cho  ;  Hye Sun Lee  ;  Jae Yong Choi  ;  Jae Hoon Lee  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Chul Hyoung Lyoo 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.47(12) : 2879-2886, 2020-11 
Journal Title
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING 
ISSN
 1619-7070 
Issue Date
2020-11
Keywords
18F-flortaucipir ; Alzheimer’s disease ; Positron emission tomography ; Tau
Abstract
Purpose: To investigate the temporal trajectories of tau and amyloid-β (Aβ) accumulation in Alzheimer's disease (AD) by using the longitudinal positron emission tomography (PET) study. Methods: A total of 132 participants, who were healthy volunteers or recruited in our memory disorder clinic, completed longitudinal 18F-flortaucipir and 18F-florbetaben PET studies with a mean follow-up time of 2 years. Referencing baseline data from 57 Aβ-negative cognitively unimpaired individuals, Z-scores and their annual changes were calculated with the global cortical or regional standardized uptake value ratios measured at baseline and follow-up after correcting for partial volume effect. The temporal trajectories of tau and Aβ burden as a function of time were obtained based on the spline models from the annual changes and baseline Z-score data. Results: Tau burden first emerged in the Braak's stage I-II regions, followed by stage III-IV regions, and finally in the stage V-VI regions. Time intervals between two time points at which Z-score curves rose above 2 were 17.3 years for the stages I-II and III-IV and 15.2 years for the stages III-IV and V-VI. Rise in the tau curve for stages I-II preceded that for global cortical Aβ, while the rise in global cortical Aβ curve preceded that for global cortical tau. Aβ accumulation rate was attenuated during the surge in tau burden in the global cortex and reached a plateau. Conclusion: Sequential appearance of Aβ and tau accumulation supports a hypothetical dynamic biomarker model and Braak's hierarchical tau spreading model in AD.
Full Text
https://link.springer.com/article/10.1007%2Fs00259-020-04773-3
DOI
10.1007/s00259-020-04773-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Baek, Min Seok(백민석) ORCID logo https://orcid.org/0000-0001-5250-9480
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180308
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