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Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer's disease

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author백민석-
dc.contributor.author유영훈-
dc.contributor.author이명식-
dc.contributor.author이재훈-
dc.contributor.author이혜선-
dc.contributor.author조한나-
dc.contributor.author최재용-
dc.date.accessioned2020-12-01T17:30:34Z-
dc.date.available2020-12-01T17:30:34Z-
dc.date.issued2020-11-
dc.identifier.issn1619-7070-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180308-
dc.description.abstractPurpose: To investigate the temporal trajectories of tau and amyloid-β (Aβ) accumulation in Alzheimer's disease (AD) by using the longitudinal positron emission tomography (PET) study. Methods: A total of 132 participants, who were healthy volunteers or recruited in our memory disorder clinic, completed longitudinal 18F-flortaucipir and 18F-florbetaben PET studies with a mean follow-up time of 2 years. Referencing baseline data from 57 Aβ-negative cognitively unimpaired individuals, Z-scores and their annual changes were calculated with the global cortical or regional standardized uptake value ratios measured at baseline and follow-up after correcting for partial volume effect. The temporal trajectories of tau and Aβ burden as a function of time were obtained based on the spline models from the annual changes and baseline Z-score data. Results: Tau burden first emerged in the Braak's stage I-II regions, followed by stage III-IV regions, and finally in the stage V-VI regions. Time intervals between two time points at which Z-score curves rose above 2 were 17.3 years for the stages I-II and III-IV and 15.2 years for the stages III-IV and V-VI. Rise in the tau curve for stages I-II preceded that for global cortical Aβ, while the rise in global cortical Aβ curve preceded that for global cortical tau. Aβ accumulation rate was attenuated during the surge in tau burden in the global cortex and reached a plateau. Conclusion: Sequential appearance of Aβ and tau accumulation supports a hypothetical dynamic biomarker model and Braak's hierarchical tau spreading model in AD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag Berlin-
dc.relation.isPartOfEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTemporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorMin Seok Baek-
dc.contributor.googleauthorHanna Cho-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJae Yong Choi-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorMyung Sik Lee-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.identifier.doi10.1007/s00259-020-04773-3-
dc.contributor.localIdA01333-
dc.contributor.localIdA04947-
dc.contributor.localIdA04947-
dc.contributor.localIdA02485-
dc.contributor.localIdA02485-
dc.contributor.localIdA02753-
dc.contributor.localIdA02753-
dc.contributor.localIdA03093-
dc.contributor.localIdA03093-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA03920-
dc.contributor.localIdA03920-
dc.contributor.localIdA04695-
dc.contributor.localIdA04695-
dc.relation.journalcodeJ00833-
dc.identifier.eissn1619-7089-
dc.identifier.pmid32350558-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00259-020-04773-3-
dc.subject.keyword18F-flortaucipir-
dc.subject.keywordAlzheimer’s disease-
dc.subject.keywordPositron emission tomography-
dc.subject.keywordTau-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthor류철형-
dc.contributor.affiliatedAuthor백민석-
dc.contributor.affiliatedAuthor백민석-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor유영훈-
dc.contributor.affiliatedAuthor이명식-
dc.contributor.affiliatedAuthor이명식-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor이재훈-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor조한나-
dc.contributor.affiliatedAuthor최재용-
dc.contributor.affiliatedAuthor최재용-
dc.citation.volume47-
dc.citation.number12-
dc.citation.startPage2879-
dc.citation.endPage2886-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Vol.47(12) : 2879-2886, 2020-11-
dc.identifier.rimsid67446-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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