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Comprehensive Immuno-Molecular Profiles for Liposarcoma: Roles of Programmed Death Ligand 1, Microsatellite Instability, and PIK3CA

 Hyae Min Jeon  ;  Jae Seok Lee  ;  Soo Hee Kim  ;  Kum-Hee Yun  ;  Kyu Hyun Park  ;  Min Kyung Jeon  ;  Young Han Lee  ;  Hong In Yoon  ;  Jin-Suck Suh  ;  Hyuk Hur  ;  Kyung Sik Kim  ;  Sunghoon Kim  ;  Seung Hyun Kim  ;  Hyo Song Kim 
 ONCOLOGY, Vol.98(11) : 817-826, 2020-09 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen / biosynthesis* ; B7-H1 Antigen / immunology ; Class I Phosphatidylinositol 3-Kinases / genetics* ; Class I Phosphatidylinositol 3-Kinases / immunology ; Cohort Studies ; Female ; Gene Amplification ; Humans ; Immunohistochemistry ; Liposarcoma / genetics* ; Liposarcoma / immunology* ; Liposarcoma / pathology ; Liposarcoma / surgery ; Lymphocytes, Tumor-Infiltrating / immunology ; Lymphocytes, Tumor-Infiltrating / pathology ; Male ; Microsatellite Instability ; Middle Aged ; Mutation ; Retrospective Studies ; Young Adult
Liposarcoma ; Microsatellite instability ; Molecular subtypes ; PIK3CA ; Programmed Death Ligand 1
Background: Developing personalized strategies for cancer has shown good efficacies. Methods: We assessed the molecular targets programmed death ligand 1 (PD-L1), microsatellite instability (MSI), and PIK3CA. Seventy-four patients with liposarcomas who underwent curative resection were assessed for PD-L1 expression in the tumor and tumor-infiltrating lymphocytes (TILs), mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6) by immunohistochemistry, MSI using polymerase chain reaction, and PIK3CA mutation/amplification using pyrosequencing and fluorescence in situ hybridization. Results: Seventeen (23%) cases were TIL+ (≥1 + expression) and associated with longer 5-year overall survival than those with TIL- tumors (84.4 vs. 60.8%, p = 0.007). Six (35.3%) PD-L1+ tumors were detected only in TIL+ cases, with none detected in tumor cells. Two well-differentiated liposarcomas showed MSI, one low and one high with concurrent loss of MLH1, MSH6, and PMS2. PIK3CA mutation was detected in 7 (9.5%) [exon 9 (n = 4) and exon 20 (n = 3)] and only 1 Q546K mutation was a PD-L1+ tumor. PIK3CA copy number gain was detected in 18 (24.4%) and was associated with TIL+ tumors (p = 0.045). Conclusions: Our comprehensive immuno-molecular panel suggests that liposarcoma should be categorized based on the molecular genomic subtype for precision medicine.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Sung Hoon(김성훈) ORCID logo https://orcid.org/0000-0002-1645-7473
Kim, Seung Hyun(김승현) ORCID logo https://orcid.org/0000-0002-3878-1944
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Jeon, Min Kyung(전민경)
Hur, Hyuk(허혁) ORCID logo https://orcid.org/0000-0002-9864-7229
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