Cited 3 times in
Comprehensive Immuno-Molecular Profiles for Liposarcoma: Roles of Programmed Death Ligand 1, Microsatellite Instability, and PIK3CA
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김승현 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 서진석 | - |
dc.contributor.author | 윤홍인 | - |
dc.contributor.author | 이영한 | - |
dc.contributor.author | 전민경 | - |
dc.contributor.author | 허혁 | - |
dc.date.accessioned | 2020-12-01T17:15:32Z | - |
dc.date.available | 2020-12-01T17:15:32Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180188 | - |
dc.description.abstract | Background: Developing personalized strategies for cancer has shown good efficacies. Methods: We assessed the molecular targets programmed death ligand 1 (PD-L1), microsatellite instability (MSI), and PIK3CA. Seventy-four patients with liposarcomas who underwent curative resection were assessed for PD-L1 expression in the tumor and tumor-infiltrating lymphocytes (TILs), mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6) by immunohistochemistry, MSI using polymerase chain reaction, and PIK3CA mutation/amplification using pyrosequencing and fluorescence in situ hybridization. Results: Seventeen (23%) cases were TIL+ (≥1 + expression) and associated with longer 5-year overall survival than those with TIL- tumors (84.4 vs. 60.8%, p = 0.007). Six (35.3%) PD-L1+ tumors were detected only in TIL+ cases, with none detected in tumor cells. Two well-differentiated liposarcomas showed MSI, one low and one high with concurrent loss of MLH1, MSH6, and PMS2. PIK3CA mutation was detected in 7 (9.5%) [exon 9 (n = 4) and exon 20 (n = 3)] and only 1 Q546K mutation was a PD-L1+ tumor. PIK3CA copy number gain was detected in 18 (24.4%) and was associated with TIL+ tumors (p = 0.045). Conclusions: Our comprehensive immuno-molecular panel suggests that liposarcoma should be categorized based on the molecular genomic subtype for precision medicine. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | B7-H1 Antigen / biosynthesis* | - |
dc.subject.MESH | B7-H1 Antigen / immunology | - |
dc.subject.MESH | Class I Phosphatidylinositol 3-Kinases / genetics* | - |
dc.subject.MESH | Class I Phosphatidylinositol 3-Kinases / immunology | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Amplification | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Liposarcoma / genetics* | - |
dc.subject.MESH | Liposarcoma / immunology* | - |
dc.subject.MESH | Liposarcoma / pathology | - |
dc.subject.MESH | Liposarcoma / surgery | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating / immunology | - |
dc.subject.MESH | Lymphocytes, Tumor-Infiltrating / pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microsatellite Instability | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Young Adult | - |
dc.title | Comprehensive Immuno-Molecular Profiles for Liposarcoma: Roles of Programmed Death Ligand 1, Microsatellite Instability, and PIK3CA | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Hyae Min Jeon | - |
dc.contributor.googleauthor | Jae Seok Lee | - |
dc.contributor.googleauthor | Soo Hee Kim | - |
dc.contributor.googleauthor | Kum-Hee Yun | - |
dc.contributor.googleauthor | Kyu Hyun Park | - |
dc.contributor.googleauthor | Min Kyung Jeon | - |
dc.contributor.googleauthor | Young Han Lee | - |
dc.contributor.googleauthor | Hong In Yoon | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Hyuk Hur | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Seung Hyun Kim | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.identifier.doi | 10.1159/000509004 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00662 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04777 | - |
dc.contributor.localId | A02967 | - |
dc.contributor.localId | A05978 | - |
dc.contributor.localId | A04373 | - |
dc.relation.journalcode | J02416 | - |
dc.identifier.eissn | 1423-0232 | - |
dc.identifier.pmid | 32892196 | - |
dc.identifier.url | https://www.karger.com/Article/FullText/509004 | - |
dc.subject.keyword | Liposarcoma | - |
dc.subject.keyword | Microsatellite instability | - |
dc.subject.keyword | Molecular subtypes | - |
dc.subject.keyword | PIK3CA | - |
dc.subject.keyword | Programmed Death Ligand 1 | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | 김경식 | - |
dc.contributor.affiliatedAuthor | 김성훈 | - |
dc.contributor.affiliatedAuthor | 김승현 | - |
dc.contributor.affiliatedAuthor | 김효송 | - |
dc.contributor.affiliatedAuthor | 서진석 | - |
dc.contributor.affiliatedAuthor | 윤홍인 | - |
dc.contributor.affiliatedAuthor | 이영한 | - |
dc.contributor.affiliatedAuthor | 전민경 | - |
dc.contributor.affiliatedAuthor | 허혁 | - |
dc.citation.volume | 98 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 817 | - |
dc.citation.endPage | 826 | - |
dc.identifier.bibliographicCitation | ONCOLOGY, Vol.98(11) : 817-826, 2020-09 | - |
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