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Serum γ-glutamyltransferase as an independent predictor for incident type 2 diabetes in middle-aged and older adults: Findings from the KoGES over 12 years of follow-up

Authors
 Jun-Hyuk Lee  ;  Hye Sun Lee  ;  Yong-Jae Lee 
Citation
 NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol.30(9) : 1484-1491, 2020-08 
Journal Title
 NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 
ISSN
 0939-4753 
Issue Date
2020-08
Keywords
Incident type 2 diabetes ; Prospective cohort study ; Serum γ-glutamyltransferase
Abstract
Backgrounds and aims: Limited evidence is available on whether serum γ-glutamyltransferase (GGT) has value as a predictor of type 2 diabetes in East Asian populations. We investigated the causal relationship between serum GGT level and incident type 2 diabetes in Korean adults. Methods and results: A total of 7739 nondiabetic adults aged 40-69 years from the Korean Genome and Epidemiology Study were studied. We divided the population into four groups according to sex-specific quartiles by serum GGT levels. Hazard ratios (HRs) with 95% Confidence intervals (CIs) for incident type 2 diabetes were prospectively analyzed using multivariate Cox proportional hazards regression models. A total of 1432 (18.5%) participants developed type 2 diabetes over 12 years of follow-up. The higher the serum GGT group quartile, the higher the cumulative type 2 diabetes incidence over 12 years with significance in both sexes (log-rank test P < 0.001). HRs (95% CIs) for incident type 2 diabetes for the highest quartile versus referent lowest quartile for serum GGT levels were 2.55 (1.86-3.51) for men and 1.90 (1.40-2.58) for women after adjusting for confounding variables. Conclusions: Higher serum GGT levels preceded and positively associated with incident type 2 diabetes among community-dwelling middle-aged and older Korean adults.
Full Text
https://www.sciencedirect.com/science/article/pii/S0939475320301496
DOI
10.1016/j.numecd.2020.04.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Jun-Hyuk(이준혁) ORCID logo https://orcid.org/0000-0002-1007-1633
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179708
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