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Serum γ-glutamyltransferase as an independent predictor for incident type 2 diabetes in middle-aged and older adults: Findings from the KoGES over 12 years of follow-up
DC Field | Value | Language |
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dc.contributor.author | 이용제 | - |
dc.contributor.author | 이준혁 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2020-10-04T16:53:55Z | - |
dc.date.available | 2020-10-04T16:53:55Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 0939-4753 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179708 | - |
dc.description.abstract | Backgrounds and aims: Limited evidence is available on whether serum γ-glutamyltransferase (GGT) has value as a predictor of type 2 diabetes in East Asian populations. We investigated the causal relationship between serum GGT level and incident type 2 diabetes in Korean adults. Methods and results: A total of 7739 nondiabetic adults aged 40-69 years from the Korean Genome and Epidemiology Study were studied. We divided the population into four groups according to sex-specific quartiles by serum GGT levels. Hazard ratios (HRs) with 95% Confidence intervals (CIs) for incident type 2 diabetes were prospectively analyzed using multivariate Cox proportional hazards regression models. A total of 1432 (18.5%) participants developed type 2 diabetes over 12 years of follow-up. The higher the serum GGT group quartile, the higher the cumulative type 2 diabetes incidence over 12 years with significance in both sexes (log-rank test P < 0.001). HRs (95% CIs) for incident type 2 diabetes for the highest quartile versus referent lowest quartile for serum GGT levels were 2.55 (1.86-3.51) for men and 1.90 (1.40-2.58) for women after adjusting for confounding variables. Conclusions: Higher serum GGT levels preceded and positively associated with incident type 2 diabetes among community-dwelling middle-aged and older Korean adults. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Serum γ-glutamyltransferase as an independent predictor for incident type 2 diabetes in middle-aged and older adults: Findings from the KoGES over 12 years of follow-up | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Jun-Hyuk Lee | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.identifier.doi | 10.1016/j.numecd.2020.04.027 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A05837 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J02400 | - |
dc.identifier.eissn | 1590-3729 | - |
dc.identifier.pmid | 32600956 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0939475320301496 | - |
dc.subject.keyword | Incident type 2 diabetes | - |
dc.subject.keyword | Prospective cohort study | - |
dc.subject.keyword | Serum γ-glutamyltransferase | - |
dc.contributor.alternativeName | Lee, Yong Jae | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 이준혁 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 30 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1484 | - |
dc.citation.endPage | 1491 | - |
dc.identifier.bibliographicCitation | NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, Vol.30(9) : 1484-1491, 2020-08 | - |
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