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Serum alkaline phosphatase level is positively associated with metabolic syndrome: A nationwide population-based study

 Ji-Hye Kim  ;  Hye Sun Lee  ;  Hye-Min Park  ;  Yong-Jae Lee 
 CLINICA CHIMICA ACTA, Vol.500 : 189-194, 2020 
Journal Title
Issue Date
Alkaline phosphatase ; Inflammation ; Insulin resistance ; Metabolic syndrome
BACKGROUND: Serum alkaline phosphatase (ALP), a useful marker of hepatobiliary or bone disorder, has recently emerged as a biomarker of chronic low-grade inflammation and cardiometabolic disease. This study aimed to examine the association of serum ALP level with metabolic syndrome (MetS) in apparently healthy adults. METHODS: A cross-sectional study was conducted to examine the relationship between serum ALP level and MetS in 7,101 men and 8,873 women aged 19 to 75 years using data from the 2008 to 2011 Korean National Health and Nutrition Examination Survey. The odds ratios (ORs) and 95% confidence intervals (CIs) for MetS were calculated using multiple logistic regression analyses across serum ALP quartiles (Q1: ≤190 U/L; Q2: 191-224 U/L; Q3: 225-263 U/L; and Q4: ≥264 U/L for men and Q1: ≤163 U/L; Q2: 164-201 U/L; Q3: 202-251 U/L; and Q4: ≥252 U/L for women). RESULTS: The mean values of most cardiometabolic variables, HOMA-IR, and leukocyte count gradually increased with serum ALP quartile. The prevalence of MetS significantly increased in accordance with serum ALP quartile. In comparison with those of individuals in the lowest quartile, the OR (95% CI) for MetS in the highest quartile was 1.32 (1.05-1.64) in men and 1.99 (1.42-3.81) in women after adjusting for age, cigarette smoking, alcohol intake, regular exercise, household income, education level, occupation, AST, ALT, and GGT levels. CONCLUSION: Serum ALP level was positively and independently associated with MetS in men and women.
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Appears in Collections:
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Ji-Hye(김지혜) ORCID logo https://orcid.org/0000-0002-5719-8180
Park, Hye-Min(박혜민)
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
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