0 49

Cited 3 times in

A novel effect of rebamipide: generation of Ca oscillations through activation of CCk1 receptors in rat pancreatic acinar cells

Authors
 Seok Jun Moon  ;  Wooin Ahn  ;  Min Goo Lee  ;  Hyeyoung Kim  ;  Syng-Ill Lee  ;  Jeong Taeg Seo  ;  R.Maynard Case  ;  Kyung Hwan Kim 
Citation
 European Journal of Pharmacology, Vol.388(1) : 17-20, 2000 
Journal Title
 European Journal of Pharmacology 
ISSN
 0014-2999 
Issue Date
2000
MeSH
Alanine/analogs & derivatives* ; Alanine/antagonists & inhibitors ; Alanine/pharmacology ; Animals ; Anti-Ulcer Agents/antagonists & inhibitors ; Anti-Ulcer Agents/pharmacology* ; Atropine/pharmacology ; Benzodiazepinones/pharmacology ; Calcium/metabolism* ; Devazepide/pharmacology ; Fluorescent Dyes ; Fura-2 ; In Vitro Techniques ; Male ; Muscarinic Antagonists/pharmacology ; Pancreas/cytology ; Pancreas/drug effects ; Pancreas/metabolism* ; Phenylurea Compounds/pharmacology ; Quinolones/antagonists & inhibitors ; Quinolones/pharmacology* ; Rats ; Rats, Sprague-Dawley ; Receptors, Cholecystokinin/drug effects ; Receptors, Cholecystokinin/metabolism*
Keywords
Rebamipide ; CCK1 receptor ; [Ca2+]i oscillation ; Pancreatic acinar cell
Abstract
The protective effect of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]-propionic acid (rebamipide) on gastric mucosa is well established. Here we demonstrate that rebamipide acts on pancreatic acinar cells to generate oscillations of intracellular Ca(2+) concentration ([Ca(2+)](i)) through the activation of cholecystokinin subtype 1 (CCK(1)) receptors. At concentrations higher than 5 microM, rebamipide induced [Ca(2+)](i) oscillations in individual fura-2-loaded pancreatic acinar cells. The frequency of oscillations increased with increasing concentrations of rebamipide, while the latency between stimulation of cells and initiation of [Ca(2+)](i) oscillations decreased with increasing concentration. The [Ca(2+)](i) oscillations evoked by rebamipide were inhibited by the CCK(1) receptor antagonist L-364,718 but not by atropine or the CCK(2) receptor antagonist L-365,260 indicating that rebamipide is a nonpeptide CCK(1) receptor agonist.
Full Text
https://www.sciencedirect.com/science/article/pii/S0014299999008493
DOI
10.1016/S0014-2999(99)00849-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Hwan(김경환)
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171629
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse