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A novel effect of rebamipide: generation of Ca oscillations through activation of CCk1 receptors in rat pancreatic acinar cells

DC Field Value Language
dc.contributor.author김경환-
dc.contributor.author문석준-
dc.contributor.author서정택-
dc.contributor.author이민구-
dc.date.accessioned2019-11-11T05:07:20Z-
dc.date.available2019-11-11T05:07:20Z-
dc.date.issued2000-
dc.identifier.issn0014-2999-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171629-
dc.description.abstractThe protective effect of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]-propionic acid (rebamipide) on gastric mucosa is well established. Here we demonstrate that rebamipide acts on pancreatic acinar cells to generate oscillations of intracellular Ca(2+) concentration ([Ca(2+)](i)) through the activation of cholecystokinin subtype 1 (CCK(1)) receptors. At concentrations higher than 5 microM, rebamipide induced [Ca(2+)](i) oscillations in individual fura-2-loaded pancreatic acinar cells. The frequency of oscillations increased with increasing concentrations of rebamipide, while the latency between stimulation of cells and initiation of [Ca(2+)](i) oscillations decreased with increasing concentration. The [Ca(2+)](i) oscillations evoked by rebamipide were inhibited by the CCK(1) receptor antagonist L-364,718 but not by atropine or the CCK(2) receptor antagonist L-365,260 indicating that rebamipide is a nonpeptide CCK(1) receptor agonist.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfEuropean Journal of Pharmacology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlanine/analogs & derivatives*-
dc.subject.MESHAlanine/antagonists & inhibitors-
dc.subject.MESHAlanine/pharmacology-
dc.subject.MESHAnimals-
dc.subject.MESHAnti-Ulcer Agents/antagonists & inhibitors-
dc.subject.MESHAnti-Ulcer Agents/pharmacology*-
dc.subject.MESHAtropine/pharmacology-
dc.subject.MESHBenzodiazepinones/pharmacology-
dc.subject.MESHCalcium/metabolism*-
dc.subject.MESHDevazepide/pharmacology-
dc.subject.MESHFluorescent Dyes-
dc.subject.MESHFura-2-
dc.subject.MESHIn Vitro Techniques-
dc.subject.MESHMale-
dc.subject.MESHMuscarinic Antagonists/pharmacology-
dc.subject.MESHPancreas/cytology-
dc.subject.MESHPancreas/drug effects-
dc.subject.MESHPancreas/metabolism*-
dc.subject.MESHPhenylurea Compounds/pharmacology-
dc.subject.MESHQuinolones/antagonists & inhibitors-
dc.subject.MESHQuinolones/pharmacology*-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, Cholecystokinin/drug effects-
dc.subject.MESHReceptors, Cholecystokinin/metabolism*-
dc.titleA novel effect of rebamipide: generation of Ca oscillations through activation of CCk1 receptors in rat pancreatic acinar cells-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pharmacology (약리학교실)-
dc.contributor.googleauthorSeok Jun Moon-
dc.contributor.googleauthorWooin Ahn-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorHyeyoung Kim-
dc.contributor.googleauthorSyng-Ill Lee-
dc.contributor.googleauthorJeong Taeg Seo-
dc.contributor.googleauthorR.Maynard Case-
dc.contributor.googleauthorKyung Hwan Kim-
dc.identifier.doi10.1016/S0014-2999(99)00849-3-
dc.contributor.localIdA00311-
dc.contributor.localIdA01358-
dc.contributor.localIdA01905-
dc.contributor.localIdA02781-
dc.relation.journalcodeJ00842-
dc.identifier.eissn1879-0712-
dc.identifier.pmid10657542-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0014299999008493-
dc.subject.keywordRebamipide-
dc.subject.keywordCCK1 receptor-
dc.subject.keyword[Ca2+]i oscillation-
dc.subject.keywordPancreatic acinar cell-
dc.contributor.alternativeNameKim, Kyung Hwan-
dc.contributor.affiliatedAuthor김경환-
dc.contributor.affiliatedAuthor문석준-
dc.contributor.affiliatedAuthor서정택-
dc.contributor.affiliatedAuthor이민구-
dc.citation.volume388-
dc.citation.number1-
dc.citation.startPage17-
dc.citation.endPage20-
dc.identifier.bibliographicCitationEuropean Journal of Pharmacology, Vol.388(1) : 17-20, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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