Cited 3 times in
A novel effect of rebamipide: generation of Ca oscillations through activation of CCk1 receptors in rat pancreatic acinar cells
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.contributor.author | 문석준 | - |
dc.contributor.author | 서정택 | - |
dc.contributor.author | 이민구 | - |
dc.date.accessioned | 2019-11-11T05:07:20Z | - |
dc.date.available | 2019-11-11T05:07:20Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171629 | - |
dc.description.abstract | The protective effect of 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]-propionic acid (rebamipide) on gastric mucosa is well established. Here we demonstrate that rebamipide acts on pancreatic acinar cells to generate oscillations of intracellular Ca(2+) concentration ([Ca(2+)](i)) through the activation of cholecystokinin subtype 1 (CCK(1)) receptors. At concentrations higher than 5 microM, rebamipide induced [Ca(2+)](i) oscillations in individual fura-2-loaded pancreatic acinar cells. The frequency of oscillations increased with increasing concentrations of rebamipide, while the latency between stimulation of cells and initiation of [Ca(2+)](i) oscillations decreased with increasing concentration. The [Ca(2+)](i) oscillations evoked by rebamipide were inhibited by the CCK(1) receptor antagonist L-364,718 but not by atropine or the CCK(2) receptor antagonist L-365,260 indicating that rebamipide is a nonpeptide CCK(1) receptor agonist. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | European Journal of Pharmacology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alanine/analogs & derivatives* | - |
dc.subject.MESH | Alanine/antagonists & inhibitors | - |
dc.subject.MESH | Alanine/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Ulcer Agents/antagonists & inhibitors | - |
dc.subject.MESH | Anti-Ulcer Agents/pharmacology* | - |
dc.subject.MESH | Atropine/pharmacology | - |
dc.subject.MESH | Benzodiazepinones/pharmacology | - |
dc.subject.MESH | Calcium/metabolism* | - |
dc.subject.MESH | Devazepide/pharmacology | - |
dc.subject.MESH | Fluorescent Dyes | - |
dc.subject.MESH | Fura-2 | - |
dc.subject.MESH | In Vitro Techniques | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Muscarinic Antagonists/pharmacology | - |
dc.subject.MESH | Pancreas/cytology | - |
dc.subject.MESH | Pancreas/drug effects | - |
dc.subject.MESH | Pancreas/metabolism* | - |
dc.subject.MESH | Phenylurea Compounds/pharmacology | - |
dc.subject.MESH | Quinolones/antagonists & inhibitors | - |
dc.subject.MESH | Quinolones/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, Cholecystokinin/drug effects | - |
dc.subject.MESH | Receptors, Cholecystokinin/metabolism* | - |
dc.title | A novel effect of rebamipide: generation of Ca oscillations through activation of CCk1 receptors in rat pancreatic acinar cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.contributor.googleauthor | Wooin Ahn | - |
dc.contributor.googleauthor | Min Goo Lee | - |
dc.contributor.googleauthor | Hyeyoung Kim | - |
dc.contributor.googleauthor | Syng-Ill Lee | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.contributor.googleauthor | R.Maynard Case | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.identifier.doi | 10.1016/S0014-2999(99)00849-3 | - |
dc.contributor.localId | A00311 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A01905 | - |
dc.contributor.localId | A02781 | - |
dc.relation.journalcode | J00842 | - |
dc.identifier.eissn | 1879-0712 | - |
dc.identifier.pmid | 10657542 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0014299999008493 | - |
dc.subject.keyword | Rebamipide | - |
dc.subject.keyword | CCK1 receptor | - |
dc.subject.keyword | [Ca2+]i oscillation | - |
dc.subject.keyword | Pancreatic acinar cell | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.contributor.affiliatedAuthor | 문석준 | - |
dc.contributor.affiliatedAuthor | 서정택 | - |
dc.contributor.affiliatedAuthor | 이민구 | - |
dc.citation.volume | 388 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 20 | - |
dc.identifier.bibliographicCitation | European Journal of Pharmacology, Vol.388(1) : 17-20, 2000 | - |
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