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Association between circadian preference and blood lipid levels using a 1:1:1 propensity score matching analysis

Authors
 Yu-Jin Kwon  ;  Tae-Ha Chung  ;  Hye Sun Lee  ;  JuYoung Park  ;  Ji-Youn Chung  ;  Byoung-Kwon Lee  ;  Ji-Won Lee 
Citation
 Journal of Clinical Lipidology, Vol.13(4) : 645-653.e2, 2019 
Journal Title
 Journal of Clinical Lipidology 
ISSN
 1933-2874 
Issue Date
2019
Keywords
Circadian preference ; Lipid profile ; Morningness-Eveningness Questionnaire
Abstract
BACKGROUND: Previous studies indicate that circadian preference is associated with various energy metabolism and metabolic disorders. However, little is known about the associations between a circadian rhythm and blood lipid levels, especially in humans. OBJECTIVE: The aim of the study was to investigate whether the circadian rhythm affects serum lipid levels in Korean adults. METHODS: We designed a cross-sectional study to evaluate the associations between circadian preference and blood lipid levels in Korean adults. A total of 1984 participants (range of age 19-81 years) were included in this study. Propensity scores were calculated using logistic regression with age, sex, and body mass index. A total of 435 subjects were evaluated by propensity score matching analysis, equally distributed into morningness, intermediate, and eveningness groups, each with 145 subjects. Circadian preference was evaluated by the Morningness-Eveningness Questionnaire. RESULTS: Participants with the evening preference had significantly higher levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C) when compared with those with morning or intermediate preference, after adjusting for confounding variables. Regarding other lipid parameters, both total cholesterol/HDL-C and low-density lipoprotein cholesterol/HDL-C in the evening preference are significantly higher than those of other circadian preferences. Evening preference was also significantly associated with a higher atherogenic index of plasma. CONCLUSION: Our study demonstrates that there is a significant association between circadian preference and blood lipid levels. Our findings suggest that individuals with evening preference could have a greater risk of atherosclerotic cardiovascular diseases.
Full Text
https://www.sciencedirect.com/science/article/pii/S1933287419300832
DOI
10.1016/j.jacl.2019.04.007
Appears in Collections:
7. Others (기타) > Gangnam Severance Hospital (강남세브란스병원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Park, JuYoung(박주영)
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Chung, Ji Youn(정지연)
Chung, Tae-Ha(정태하) ORCID logo https://orcid.org/0000-0001-5873-3352
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171387
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