17 27

Cited 0 times in

Association between Resting Heart Rate and Colorectal Cancer: Results from a Case-Controlled Study

Authors
 Yu-Jin Kwon  ;  Hye Sun Lee  ;  Mi Ra Cho  ;  Si Nae Kim  ;  Justin Y. Jeon  ;  Nam Kyu Kim  ;  Ji-Won Lee 
Citation
 International Journal of Environmental Research and Public Health, Vol.16(16) : E2883, 2019 
Journal Title
 International Journal of Environmental Research and Public Health 
ISSN
 1661-7827 
Issue Date
2019
Abstract
Previous studies evaluating associations between resting heart rate (RHR) and cancer-related mortality/prognosis have yielded conflicting results. We investigated whether elevations in RHR are associated with colorectal cancer (CRC). We conducted a case-controlled study involving 1241 CRC patients and 5909 cancer-free controls from the Korean National Health and Nutrition Examination Survey. After propensity score (PS) matching, 1207 CRC patients and 1207 matched controls were analyzed. Associations between RHR and CRC, colon, and rectal cancer were analyzed in appropriate patient subgroups using multiple and conditional logistic regression. Receiver operating characteristics analysis yielded the optimal RHR cut-point to predict CRC. RHR was significantly higher in CRC, colon, and rectal cancer patients than in controls (72.7 bpm in CRC, 72.8 bpm in colon cancer, 72.3 bpm in rectal cancer, and 68.7 bpm in controls; all p < 0.001). Analysis of data prior to PS matching yielded the following odds ratios (ORs) per RHR increment for CRC, colon, and rectal cancer: 1.043 (95% confidence intervals (CIs): 1.036-1.049), 1.045 (95% CI: 1.037-1.053), and 1.040 (95% CI: 1.030-1.051), respectively, in unadjusted models, and 1.043 (95% CI: 1.034-1.051), 1.046 (95% CI: 1.037-1.055), and 1.040 (95% CI: 1.027-1.052), respectively, in multivariable adjusted models. Patients with CRC, colon, and rectal cancer have a significantly higher RHR compared to cancer-free controls.
Files in This Item:
T201903415.pdf Download
DOI
10.3390/ijerph16162883
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwon, Yu-Jin(권유진) ORCID logo https://orcid.org/0000-0002-9021-3856
Kim, Nam Kyu(김남규) ORCID logo https://orcid.org/0000-0003-0639-5632
Kim, Si Nae(김시내)
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, Mi Ra(조미라)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171361
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse