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Association between Resting Heart Rate and Colorectal Cancer: Results from a Case-Controlled Study

DC Field Value Language
dc.contributor.author김남규-
dc.contributor.author이지원-
dc.contributor.author이혜선-
dc.contributor.author권유진-
dc.contributor.author김시내-
dc.contributor.author조미라-
dc.date.accessioned2019-10-28T01:50:32Z-
dc.date.available2019-10-28T01:50:32Z-
dc.date.issued2019-
dc.identifier.issn1661-7827-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171361-
dc.description.abstractPrevious studies evaluating associations between resting heart rate (RHR) and cancer-related mortality/prognosis have yielded conflicting results. We investigated whether elevations in RHR are associated with colorectal cancer (CRC). We conducted a case-controlled study involving 1241 CRC patients and 5909 cancer-free controls from the Korean National Health and Nutrition Examination Survey. After propensity score (PS) matching, 1207 CRC patients and 1207 matched controls were analyzed. Associations between RHR and CRC, colon, and rectal cancer were analyzed in appropriate patient subgroups using multiple and conditional logistic regression. Receiver operating characteristics analysis yielded the optimal RHR cut-point to predict CRC. RHR was significantly higher in CRC, colon, and rectal cancer patients than in controls (72.7 bpm in CRC, 72.8 bpm in colon cancer, 72.3 bpm in rectal cancer, and 68.7 bpm in controls; all p < 0.001). Analysis of data prior to PS matching yielded the following odds ratios (ORs) per RHR increment for CRC, colon, and rectal cancer: 1.043 (95% confidence intervals (CIs): 1.036-1.049), 1.045 (95% CI: 1.037-1.053), and 1.040 (95% CI: 1.030-1.051), respectively, in unadjusted models, and 1.043 (95% CI: 1.034-1.051), 1.046 (95% CI: 1.037-1.055), and 1.040 (95% CI: 1.027-1.052), respectively, in multivariable adjusted models. Patients with CRC, colon, and rectal cancer have a significantly higher RHR compared to cancer-free controls.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfInternational Journal of Environmental Research and Public Health-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation between Resting Heart Rate and Colorectal Cancer: Results from a Case-Controlled Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorYu-Jin Kwon-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorMi Ra Cho-
dc.contributor.googleauthorSi Nae Kim-
dc.contributor.googleauthorJustin Y. Jeon-
dc.contributor.googleauthorNam Kyu Kim-
dc.contributor.googleauthorJi-Won Lee-
dc.identifier.doi10.3390/ijerph16162883-
dc.contributor.localIdA00353-
dc.contributor.localIdA03203-
dc.contributor.localIdA03312-
dc.contributor.localIdA04882-
dc.contributor.localIdA05313-
dc.contributor.localIdA05417-
dc.relation.journalcodeJ01111-
dc.identifier.eissn1660-4601-
dc.identifier.pmid31409045-
dc.contributor.alternativeNameKim, Nam Kyu-
dc.contributor.affiliatedAuthor김남규-
dc.contributor.affiliatedAuthor이지원-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor권유진-
dc.contributor.affiliatedAuthor김시내-
dc.contributor.affiliatedAuthor조미라-
dc.citation.volume16-
dc.citation.number16-
dc.citation.startPageE2883-
dc.identifier.bibliographicCitationInternational Journal of Environmental Research and Public Health, Vol.16(16) : E2883, 2019-
dc.identifier.rimsid63902-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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