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Liver Fibrosis, Not Steatosis, Associates with Long-Term Outcomes in Ischaemic Stroke Patients

 Baik M.  ;  Kim S.U.  ;  Kang S.  ;  Park H.J.  ;  Nam H.S.  ;  Heo J.H.  ;  Kim B.K.  ;  Park J.Y.  ;  Kim D.Y.  ;  Ahn S.H.  ;  Han K.-H.  ;  Lee H.S.  ;  Kim Y.D. 
 Cerebrovascular Diseases, Vol.47(1~2) : 32-39, 2019 
Journal Title
 Cerebrovascular Diseases 
Issue Date
Liver fibrosis ; Mortality ; Non-alcoholic fatty liver disease ; Stroke ; Transient elastography
BACKGROUND: To investigate whether there are differences in long-term all-cause and cardiovascular mortality according to the burden of liver fibrosis or steatosis in patients with ischaemic stroke or transient ischaemic attack (TIA). -Methods: Consecutive patients with acute ischaemic stroke or TIA who underwent transient elastography (TE) from January 2014 to December 2014 were considered eligible. The influence of liver fibrosis or steatosis, assessed via TE, on long-term outcomes was investigated using Cox proportional hazard models. RESULTS: Among 395 patients included in this study, there were 37 (9%) patients with significant fibrosis (> 8.0 kPa) and 164 (41.5%) patients with fatty liver (> 250 dB/m). During the follow-up period (median 2.7 years), all-cause and cardiovascular mortality occurred in 28 (7.1%) and 20 (5.1%) patients. On multivariate analyses, significant liver fibrosis was independently associated with increased risk of all-cause (hazard ratio [HR] 8.14, 95% CI 3.03-21.90, p < 0.001) and cardiovascular (HR 4.29, 95% CI 1.10-16.73, p = 0.036) mortality, whereas fatty liver was not (all p > 0.05). CONCLUSIONS: This study found that the burden of liver fibrosis but not that of steatosis, assessed via TE, was an independent predictor of all-cause and cardiovascular mortality during long-term follow-up in patients with ischaemic stroke.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
김도영(Kim, Do Young)
김범경(Kim, Beom Kyung) ORCID logo https://orcid.org/0000-0002-5363-2496
김승업(Kim, Seung Up) ORCID logo https://orcid.org/0000-0002-9658-8050
김영대(Kim, Young Dae) ORCID logo https://orcid.org/0000-0001-5750-2616
남효석(Nam, Hyo Suk) ORCID logo https://orcid.org/0000-0002-4415-3995
박준용(Park, Jun Yong) ORCID logo https://orcid.org/0000-0001-6324-2224
박형종(Park, Hyungjong)
안상훈(Ahn, Sang Hoon) ORCID logo https://orcid.org/0000-0002-3629-4624
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
한광협(Han, Kwang-Hyub) ORCID logo https://orcid.org/0000-0003-3960-6539
허지회(Heo, Ji Hoe) ORCID logo https://orcid.org/0000-0001-9898-3321
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