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High versus low attenuation thresholds to determine the solid component of ground-glass opacity nodules.

 Jae Ho Lee  ;  Tae Hoon Kim  ;  Sungsoo Lee  ;  Kyunghwa Han  ;  Min Kwang Byun  ;  Yoon Soo Chang  ;  Hyung Jung Kim  ;  Geun Dong Lee  ;  Chul Hwan Park 
 PLoS One, Vol.13(10) : e0205490, 2018 
Journal Title
 PLoS One 
Issue Date
OBJECTIVES: To evaluate and compare the diagnostic accuracy of high versus low attenuation thresholds for determining the solid component of ground-glass opacity nodules (GGNs) for the differential diagnosis of adenocarcinoma in situ (AIS) from minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA). METHODS: Eighty-six pathologically confirmed GGNs < 3 cm observed in 86 patients (27 male, 59 female; mean age, 59.3 ± 11.0 years) between January 2013 and December 2015 were retrospectively included. The solid component of each GGN was defined using two different attenuation thresholds: high (-160 Hounsfield units [HU]) and low (-400 HU). According to the presence or absence of solid portions, each GGN was categorized as a pure GGN or part-solid GGN. Solid components were regarded as indicators of invasive foci, suggesting MIA or IA. RESULTS: Among the 86 GGNs, there were 57 cases of IA, 19 of MIA, and 10 of AIS. Using the high attenuation threshold, 44 were categorized as pure GGNs and 42 as part-solid GGNs. Using the low attenuation threshold, 13 were categorized as pure GGNs and 73 as part-solid GGNs. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy for the invasive focus were 55.2%, 100%, 100%, 22.7%, and 60.4%, respectively, for the high attenuation threshold, and 93.4%, 80%, 97.2%, 61.5%, and 91.8%, respectively, for the low attenuation threshold. CONCLUSION: The low attenuation threshold was better than the conventional high attenuation threshold for determining the solid components of GGNs, which indicate invasive foci
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
김태훈(Kim, Tae Hoon) ORCID logo https://orcid.org/0000-0003-3598-2529
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
박철환(Park, Chul Hwan) ORCID logo https://orcid.org/0000-0002-0004-9475
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
이근동(Lee, Geun Dong)
이성수(Lee, Sung Soo) ORCID logo https://orcid.org/0000-0001-8998-9510
이재호(Lee, Jae Ho) ORCID logo https://orcid.org/0000-0002-8592-1209
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
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