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Effects of Three Calcium Silicate Cements on Inflammatory Response and Mineralization-Inducing Potentials in a Dog Pulpotomy Model.

Authors
 Chung-Min Kang  ;  Jiwon Hwang  ;  Je Seon Song  ;  Jae-Ho Lee  ;  Hyung-Jun Choi  ;  Yooseok Shin 
Citation
 Materials, Vol.11(6) : 899, 2018 
Journal Title
 Materials 
Issue Date
2018
Keywords
calcific barrier ; calcium silicate cements ; inflammation ; mineralization ; odontoblastic layer ; pulpal response
Abstract
This beagle pulpotomy study compared the inflammatory response and mineralization-inducing potential of three calcium silicate cements: ProRoot mineral trioxide aggregate (MTA) (Dentsply, Tulsa, OK, USA), OrthoMTA (BioMTA, Seoul, Korea), and Endocem MTA (Maruchi, Wonju, Korea). Exposed pulp tissues were capped with ProRoot MTA, OrthoMTA, or Endocem MTA. After 8 weeks, we extracted the teeth, then performed hematoxylin-eosin and immunohistochemical staining with osteocalcin and dentin sialoprotein. Histological evaluation comprised a scoring system with eight broad categories and analysis of calcific barrier areas. We evaluated 44 teeth capped with ProRoot MTA (n = 15), OrthoMTA (n = 18), or Endocem MTA (n = 11). Most ProRoot MTA specimens formed continuous calcific barriers; these pulps contained inflammation-free palisading patterns in the odontoblastic layer. Areas of the newly formed calcific barrier were greater with ProRoot MTA than with Endocem MTA (p = 0.006). Although dentin sialoprotein was highly expressed in all three groups, the osteocalcin expression was reduced in the OrthoMTA and Endocem MTA groups. ProRoot MTA was superior to OrthoMTA and Endocem MTA in all histological analyses. ProRoot MTA and OrthoMTA resulted in reduced pulpal inflammation and more complete calcific barrier formation, whereas Endocem MTA caused a lower level of calcific barrier continuity with tunnel defects.
Files in This Item:
T201803865.pdf Download
DOI
10.3390/ma11060899
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
Yonsei Authors
강정민(Kang, Chung Min)
송제선(Song, Je Seon) ORCID logo https://orcid.org/0000-0001-8620-5629
신유석(Shin, Yoo Seok) ORCID logo https://orcid.org/0000-0003-1121-2570
이제호(Lee, Jae Ho) ORCID logo https://orcid.org/0000-0002-1556-3485
최형준(Choi, Hyung Jun) ORCID logo https://orcid.org/0000-0002-3315-6912
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/165334
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