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High Resolution Hyperpolarized 13C MRSI using SPICE at 9.4 T

 Hansol Lee  ;  Jae Eun Song  ;  Jaewook Shin  ;  Eunhae Joe  ;  Chan Gyu Joo  ;  Young‐Suk Choi  ;  Ho‐Taek Song  ;  Dong‐Hyun Kim 
 Magnetic Resonance in Medicine, Vol.80(2) : 703-710, 2018 
Journal Title
 Magnetic Resonance in Medicine 
Issue Date
SPICE ; high resolution spectroscopic imaging ; hyperpolarized 13C ; partially separable model ; pyruvate
PURPOSE: To test the feasibility of using the SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) technique, which uses the partial separability of spectroscopic data, for high resolution hyperpolarized (HP) 13 C spectroscopic imaging. METHODS: Numerical simulations were performed to investigate the impact of transient HP signals on SPICE reconstruction. Furthermore, spectroscopic imaging exams from SPICE and conventional EPSI (echo-planar spectroscopic imaging) were simulated for comparison. For in vivo experiments, HP 13 C SPICE was performed in a mouse kidney by means of the injection of HP [1-13 C] pyruvate at 9.4T. RESULTS: The variation of lactate/pyruvate from the simulated SPICE was less than 4% under various factors that affect the transient HP signal, suggesting that the impact is negligible. We found that while HP 13 C EPSI was limited to the low signal-to-noise ratio (SNR) of lactate, these limitations were mitigated through HP 13 C SPICE, facilitating the improved SNR of lactate and the distinction of tissues. Acquisition of a high resolution HP 13 C spectroscopic image was possible for the in vivo experiments. With the fine structural information, the acquired image showed higher signal of pyruvate and lactate in the renal cortices than in the medullas, which is known to be attributed to higher activity of lactate dehydrogenase. CONCLUSION: The feasibility of HP 13 C SPICE was investigated. Simulation studies were conducted and in vivo experiments were performed in the mouse kidney at 9.4T. Results confirmed that a high resolution HP 13 C spectroscopic image with adequate spectral resolution can be obtained. Magn Reson Med 80:703-710, 2018. © 2018 International Society for Magnetic Resonance in Medicine.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Joo, Chan Gyu(주찬규) ORCID logo https://orcid.org/0000-0002-1415-9245
Choi, Young Suk(최영숙) ORCID logo https://orcid.org/0000-0003-4930-8455
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