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Effects of alternate day calorie restriction and exercise on cardio-metabolic risk factors in overweight and obese adults: an exploratory randomized controlled study

Authors
 Minsuk Oh  ;  Sue Kim  ;  Ki-Yong An  ;  Jihee Min  ;  Hyuk In Yang  ;  Junga Lee  ;  Mi Kyung Lee  ;  Dong-Il Kim  ;  Hye-Sun Lee  ;  Ji-Won Lee  ;  Justin Y. Jeon 
Citation
 BMC Public Health, Vol.18 : 1124, 2018 
Journal Title
 BMC Public Health 
Issue Date
2018
MeSH
Adult ; Blood Glucose ; Body Composition ; Body Weight ; Caloric Restriction/methods* ; Cardiovascular Diseases/prevention & control* ; Combined Modality Therapy ; Exercise Therapy/methods* ; Female ; Humans ; Insulin/blood ; Insulin Resistance ; Male ; Metabolic Diseases/prevention & control* ; Obesity/therapy* ; Overweight/therapy* ; Risk Factors ; Treatment Outcome ; Triglycerides/blood
Keywords
Alternate day calorie restriction ; Body weight ; Exercise ; Insulin resistance ; Obesity
Abstract
BACKGROUND: It has been recognized that alternate day calorie restriction (ADCR) or exercise has positive effects on cardio-metabolic risk factors. It is unclear whether the combined effect of ADCR and exercise (aerobic + resistance training) influences risk. We investigated effects of an 8-week ADCR and exercise program (aerobic + resistance training) on cardio-metabolic risk factors in overweight and obese adults. METHODS: This study randomized 45 overweight or obese but healthy adults (F = 26, M = 19; aged about 32 to 40 years) into 4 groups: ADCR (n = 13), exercise (n = 10), exercise plus ADCR (n = 12), and control (n = 10) for 8 weeks. Body composition, blood lipids profile, and insulin resistance were measured. The intention to treat (ITT) method was used to analyze all participants that were randomized. RESULTS: A total of 35 participants completed the trial (78%). Body weight, body mass index, waist circumference, fat mass and percent body fat were reduced in the exercise plus ADCR group (- 3.3 ± 2.4 kg, p < 0.01; - 1.3 ± 1.0 kg/m2, p < 0.01; - 4.1 ± 3.9 cm, p < 0.01; - 2.7 ± 2.0 kg, p < 0.01; - 2. 5 ± 2.2%, p < 0.01). Insulin, glucose, homeostasis model assessment insulin resistance and triglyceride (- 2.9 ± 4.1 μIU/ml, p < 0.05; - 10.9 ± 16.9 mg/dl, p < 0.05; - 0.9 ± 1.3, p < 0.05; - 43.8 ± 41.9 mg/dl, p < 0.01) decreased in the exercise plus ADCR group only. CONCLUSIONS: ADCR and exercise both proved to be beneficial, but the combined intervention was most effective at inducing beneficial changes in body weight, body composition, glucose, insulin, insulin resistance and triglyceride in overweight and obese adults.
Files in This Item:
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DOI
10.1186/s12889-018-6009-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
김수(Kim, Sue)
이지원(Lee, Ji Won) ORCID logo https://orcid.org/0000-0002-2666-4249
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/163494
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