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Preoperative High Neutrophil-Lymphocyte Ratio May Be Associated with Lateral Lymph Node Metastasis in Patients with Papillary Thyroid Cancers

 In Hye Chae  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon  ;  Vivian Y. Park  ;  Hye Sun Lee  ;  Jieun Moon  ;  Jin Young Kwak 
 International Journal of Thyroidology, Vol.11(1) : 41-48, 2018 
Journal Title
 International Journal of Thyroidology 
Issue Date
Lymphocyte ; Lymph node metastasis ; Neutrophil ; Recurrence ; Papillary thyroid carcinoma
Background and Objectives: The present study investigated the association between preoperative neutrophilto-lymphocyte ratio (NLR) and poor prognostic outcomes in conventional papillary thyroid carcinomas (cPTCs). Materials and Methods: Two hundred and five patients who underwent total thyroidectomy for cPTCs larger than 10 mm were evaluated retrospectively. Patients were classified into the low NLR (n=103) and high NLR (n=102) groups by the median NLR value (1.78) and logistic regression analysis was used to evaluate whether the NLR predicted aggressive PTC features. Patients were also classified into the disease-free (n=183) and persistence/recurrence (n=22) groups and Cox regression analysis was used to investigate factors affecting persistence/recurrence by Cox regression analysis. Results: The high NLR group had a higher presence of lateral lymph node metastasis (p=0.004) and higher radioactive iodine doses (p=0.006) than the low NLR group. High NLR was an independent predictor of lateral lymph node metastasis (LNM) (OR, 2.786; p=0.005) but was not significantly associated with persistence/recurrence. Conclusion: Preoperative high NLR was an independent predictor of lateral LNM in cPTCs.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kwak, Jin Young(곽진영) ORCID logo https://orcid.org/0000-0002-6212-1495
Kim, Eun-Kyung(김은경) ORCID logo https://orcid.org/0000-0002-3368-5013
Moon, Hee Jung(문희정) ORCID logo https://orcid.org/0000-0002-5643-5885
Park, Vivian Youngjean(박영진) ORCID logo https://orcid.org/0000-0002-5135-4058
Yoon, Jung Hyun(윤정현) ORCID logo https://orcid.org/0000-0002-2100-3513
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
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