0 110

Cited 2 times in

Predicted sequence of cortical tau and amyloid-beta deposition in Alzheimer disease spectrum

Authors
 Hanna Cho  ;  Hye Sun Lee  ;  Jae Yong Choi  ;  Jae Hoon Lee  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Chul Hyoung Lyoo 
Citation
 Neurobiology of Aging, Vol.68 : 76-84, 2018 
Journal Title
 Neurobiology of Aging 
ISSN
 0197-4580 
Issue Date
2018
Keywords
(18)F-flortaucipir ; Alzheimer disease ; Amyloid-beta ; PET ; Tau
Abstract
We investigated sequential order between tau and amyloid-beta (Abeta) deposition in Alzheimer disease spectrum using a conditional probability method. Two hundred twenty participants underwent (18)F-flortaucipir and (18)F-florbetaben positron emission tomography scans and neuropsychological tests. The presence of tau and Abeta in each region and impairment in each cognitive domain were determined by Z-score cutoffs. By comparing pairs of conditional probabilities, the sequential order of tau and Abeta deposition were determined. Probability for the presence of tau in the entorhinal cortex was higher than that of Abeta in all cortical regions, and in the medial temporal cortices, probability for the presence of tau was higher than that of Abeta. Conversely, in the remaining neocortex above the inferior temporal cortex, probability for the presence of Abeta was always higher than that of tau. Tau pathology in the entorhinal cortex may appear earlier than neocortical Abeta and may spread in the absence of Abeta within the neighboring medial temporal regions. However, Abeta may be required for massive tau deposition in the distant cortical areas.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458018301295
DOI
10.1016/j.neurobiolaging.2018.04.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Myung Sik(이명식) ORCID logo https://orcid.org/0000-0002-8413-1854
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0002-9898-9886
Lee, Hye Sun(이혜선) ORCID logo https://orcid.org/0000-0001-6328-6948
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/162360
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse