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Cited 2 times in

Predicted sequence of cortical tau and amyloid-beta deposition in Alzheimer disease spectrum

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author유영훈-
dc.contributor.author이명식-
dc.contributor.author이재훈-
dc.contributor.author이혜선-
dc.contributor.author조한나-
dc.contributor.author최재용-
dc.date.accessioned2018-08-28T17:12:02Z-
dc.date.available2018-08-28T17:12:02Z-
dc.date.issued2018-
dc.identifier.issn0197-4580-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162360-
dc.description.abstractWe investigated sequential order between tau and amyloid-beta (Abeta) deposition in Alzheimer disease spectrum using a conditional probability method. Two hundred twenty participants underwent (18)F-flortaucipir and (18)F-florbetaben positron emission tomography scans and neuropsychological tests. The presence of tau and Abeta in each region and impairment in each cognitive domain were determined by Z-score cutoffs. By comparing pairs of conditional probabilities, the sequential order of tau and Abeta deposition were determined. Probability for the presence of tau in the entorhinal cortex was higher than that of Abeta in all cortical regions, and in the medial temporal cortices, probability for the presence of tau was higher than that of Abeta. Conversely, in the remaining neocortex above the inferior temporal cortex, probability for the presence of Abeta was always higher than that of tau. Tau pathology in the entorhinal cortex may appear earlier than neocortical Abeta and may spread in the absence of Abeta within the neighboring medial temporal regions. However, Abeta may be required for massive tau deposition in the distant cortical areas.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfNEUROBIOLOGY OF AGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePredicted sequence of cortical tau and amyloid-beta deposition in Alzheimer disease spectrum-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorHanna Cho-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJae Yong Choi-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorMyung Sik Lee-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.identifier.doi10.1016/j.neurobiolaging.2018.04.007-
dc.contributor.localIdA01333-
dc.contributor.localIdA02485-
dc.contributor.localIdA02753-
dc.contributor.localIdA03093-
dc.contributor.localIdA03312-
dc.contributor.localIdA03920-
dc.contributor.localIdA04695-
dc.relation.journalcodeJ02322-
dc.identifier.eissn1558-1497-
dc.identifier.pmid29751288-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0197458018301295-
dc.subject.keyword(18)F-flortaucipir-
dc.subject.keywordAlzheimer disease-
dc.subject.keywordAmyloid-beta-
dc.subject.keywordPET-
dc.subject.keywordTau-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameLee, Myung Sik-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameCho, Hanna-
dc.contributor.alternativeNameChoi, Jae Yong-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLee, Myung Sik-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorCho, Hanna-
dc.contributor.affiliatedAuthorChoi, Jae Yong-
dc.citation.volume68-
dc.citation.startPage76-
dc.citation.endPage84-
dc.identifier.bibliographicCitationNEUROBIOLOGY OF AGING, Vol.68 : 76-84, 2018-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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