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Serum carcinoembryonic antigen is positively associated with leukocyte count in Korean adults

 Yu-Jin Kwon  ;  Hye-Sun Lee  ;  Jae-Yong Shim  ;  Yong-Jae Lee 
 Journal of Clinical Laboratory Analysis, Vol.32(3) : e22291, 2018 
Journal Title
 Journal of Clinical Laboratory Analysis 
Issue Date
Adult ; Carcinoembryonic Antigen/*blood ; Cross-Sectional Studies ; Female ; Humans ; Inflammation ; Leukocyte Count/*statistics & numerical data ; Linear Models ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Retrospective Studies
carcinoembryonic antigen ; leukocyte count ; subclinical inflammation
BACKGROUND: Emerging evidence shows that serum carcinoembryonic antigen (CEA) levels may modestly be increased in non-neoplastic conditions such as cardiometabolic diseases, which are increasingly being seen as inflammatory diseases. Leukocyte count is widely evaluated marker of inflammation in clinical practice and a useful predictor of cardiometabolic disease. In this study, we aimed to determine the relationship between serum CEA levels and leukocyte counts in Korean adults. METHODS: This cross-sectional study included a total of 19 834 individuals enrolled from a health promotion center between November 2006 and July 2010. Multiple linear regression analysis was performed to investigate the association between serum CEA levels and leukocyte counts after adjusting for confounding variables. RESULTS: According to both stepwise-method and enter-method multiple linear regression analyses, serum CEA levels were positively and independently associated with leukocyte counts (P<.001) after adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, HDL-cholesterol, cigarette smoking, alcohol ingestion, physical activity, diabetes mellitus, and anti-inflammatory drugs. CONCLUSIONS: We demonstrate a positive relationship between serum CEA levels and leukocyte counts in Korean adults. Our results suggested that an elevated serum CEA level may reflect chronic inflammation state.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
권유진(Kwon, Yu-Jin) ORCID logo https://orcid.org/0000-0002-9021-3856
심재용(Shim, Jae Yong) ORCID logo https://orcid.org/0000-0002-9561-9230
이용제(Lee, Yong Jae) ORCID logo https://orcid.org/0000-0002-6697-476X
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
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