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Serum carcinoembryonic antigen is positively associated with leukocyte count in Korean adults

DC Field Value Language
dc.contributor.author권유진-
dc.contributor.author심재용-
dc.contributor.author이용제-
dc.contributor.author이혜선-
dc.date.accessioned2018-08-28T17:02:49Z-
dc.date.available2018-08-28T17:02:49Z-
dc.date.issued2018-
dc.identifier.issn0887-8013-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/162198-
dc.description.abstractBACKGROUND: Emerging evidence shows that serum carcinoembryonic antigen (CEA) levels may modestly be increased in non-neoplastic conditions such as cardiometabolic diseases, which are increasingly being seen as inflammatory diseases. Leukocyte count is widely evaluated marker of inflammation in clinical practice and a useful predictor of cardiometabolic disease. In this study, we aimed to determine the relationship between serum CEA levels and leukocyte counts in Korean adults. METHODS: This cross-sectional study included a total of 19 834 individuals enrolled from a health promotion center between November 2006 and July 2010. Multiple linear regression analysis was performed to investigate the association between serum CEA levels and leukocyte counts after adjusting for confounding variables. RESULTS: According to both stepwise-method and enter-method multiple linear regression analyses, serum CEA levels were positively and independently associated with leukocyte counts (P<.001) after adjusting for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, HDL-cholesterol, cigarette smoking, alcohol ingestion, physical activity, diabetes mellitus, and anti-inflammatory drugs. CONCLUSIONS: We demonstrate a positive relationship between serum CEA levels and leukocyte counts in Korean adults. Our results suggested that an elevated serum CEA level may reflect chronic inflammation state.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss, Inc.-
dc.relation.isPartOfJOURNAL OF CLINICAL LABORATORY ANALYSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHCarcinoembryonic Antigen/*blood-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHInflammation-
dc.subject.MESHLeukocyte Count/*statistics & numerical data-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.titleSerum carcinoembryonic antigen is positively associated with leukocyte count in Korean adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Family Medicine-
dc.contributor.googleauthorYu-Jin Kwon-
dc.contributor.googleauthorHye-Sun Lee-
dc.contributor.googleauthorJae-Yong Shim-
dc.contributor.googleauthorYong-Jae Lee-
dc.identifier.doi10.1002/jcla.22291-
dc.contributor.localIdA04882-
dc.contributor.localIdA02207-
dc.contributor.localIdA02982-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ01323-
dc.identifier.eissn1098-2825-
dc.identifier.pmid28653772-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jcla.22291-
dc.subject.keywordcarcinoembryonic antigen-
dc.subject.keywordleukocyte count-
dc.subject.keywordsubclinical inflammation-
dc.contributor.alternativeNameKwon, Yu-Jin-
dc.contributor.alternativeNameShim, Jae Yong-
dc.contributor.alternativeNameLee, Yong Jae-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.affiliatedAuthorKwon, Yu-Jin-
dc.contributor.affiliatedAuthorShim, Jae Yong-
dc.contributor.affiliatedAuthorLee, Yong Jae-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.citation.volume32-
dc.citation.number3-
dc.citation.startPagee22291-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL LABORATORY ANALYSIS, Vol.32(3) : e22291, 2018-
dc.identifier.rimsid59784-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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