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Off-Target (18)F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation

Authors
 Jae Yong Choi  ;  Hanna Cho  ;  Sung Jun Ahn  ;  Jae Hoon Lee  ;  Young Hoon Ryu  ;  Myung Sik Lee  ;  Chul Hyoung Lyoo 
Citation
 Journal of Nuclear Medicine, Vol.59(1) : 117-120, 2018 
Journal Title
 Journal of Nuclear Medicine 
ISSN
 0161-5505 
Issue Date
2018
Keywords
18F-AV-1451 ; PET ; aging ; basal ganglia ; iron
Abstract
Off-target binding in the basal ganglia is commonly observed in the (18)F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R2* MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent (18)F-AV-1451 PET and R2* MRI studies. A correlation analysis was performed for age, (18)F-AV-1451 binding, and R2* values. Results: There was an age-related increase in both (18)F-AV-1451 binding in the basal ganglia and R2* values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. (18)F-AV-1451 binding in the basal ganglia increased with R2* values. Conclusion: Off-target (18)F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association.
Full Text
http://jnm.snmjournals.org/content/59/1/117
DOI
10.2967/jnumed.117.195248
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
류철형(Lyoo, Chul Hyoung)
안성준(Ahn, Sung Jun) ORCID logo https://orcid.org/0000-0003-0075-2432
유영훈(Ryu, Young Hoon)
이명식(Lee, Myung Sik)
이재훈(Lee, Jae Hoon)
조한나(Cho, Hanna)
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161903
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