Cited 59 times in
Off-Target (18)F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation
DC Field | Value | Language |
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dc.contributor.author | 류철형 | - |
dc.contributor.author | 안성준 | - |
dc.contributor.author | 유영훈 | - |
dc.contributor.author | 이명식 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 조한나 | - |
dc.contributor.author | 최재용 | - |
dc.date.accessioned | 2018-08-28T16:45:13Z | - |
dc.date.available | 2018-08-28T16:45:13Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0161-5505 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161903 | - |
dc.description.abstract | Off-target binding in the basal ganglia is commonly observed in the (18)F-AV-1451 PET studies of the elderly. We sought to investigate the relationship between this phenomenon in the basal ganglia and iron accumulation using iron-sensitive R2* MRI. Methods: Fifty-nine healthy controls and 61 patients with Alzheimer disease and mild cognitive impairment underwent (18)F-AV-1451 PET and R2* MRI studies. A correlation analysis was performed for age, (18)F-AV-1451 binding, and R2* values. Results: There was an age-related increase in both (18)F-AV-1451 binding in the basal ganglia and R2* values in the putamen in both the controls and the Alzheimer disease/mild cognitive impairment patients. (18)F-AV-1451 binding in the basal ganglia increased with R2* values. Conclusion: Off-target (18)F-AV-1451 binding in the basal ganglia is associated with the age-related increases in iron accumulation. Postmortem studies are required to further investigate the nature of this association. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Society of Nuclear Medicine | - |
dc.relation.isPartOf | JOURNAL OF NUCLEAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Off-Target (18)F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurology | - |
dc.contributor.googleauthor | Jae Yong Choi | - |
dc.contributor.googleauthor | Hanna Cho | - |
dc.contributor.googleauthor | Sung Jun Ahn | - |
dc.contributor.googleauthor | Jae Hoon Lee | - |
dc.contributor.googleauthor | Young Hoon Ryu | - |
dc.contributor.googleauthor | Myung Sik Lee | - |
dc.contributor.googleauthor | Chul Hyoung Lyoo | - |
dc.identifier.doi | 10.2967/jnumed.117.195248 | - |
dc.contributor.localId | A01333 | - |
dc.contributor.localId | A02237 | - |
dc.contributor.localId | A02485 | - |
dc.contributor.localId | A02753 | - |
dc.contributor.localId | A03093 | - |
dc.contributor.localId | A03920 | - |
dc.contributor.localId | A04695 | - |
dc.relation.journalcode | J01644 | - |
dc.identifier.eissn | 1535-5667 | - |
dc.identifier.pmid | 28775201 | - |
dc.identifier.url | http://jnm.snmjournals.org/content/59/1/117 | - |
dc.subject.keyword | 18F-AV-1451 | - |
dc.subject.keyword | PET | - |
dc.subject.keyword | aging | - |
dc.subject.keyword | basal ganglia | - |
dc.subject.keyword | iron | - |
dc.contributor.alternativeName | Lyoo, Chul Hyoung | - |
dc.contributor.alternativeName | Ahn, Sung Jun | - |
dc.contributor.alternativeName | Ryu, Young Hoon | - |
dc.contributor.alternativeName | Lee, Myung Sik | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.alternativeName | Cho, Hanna | - |
dc.contributor.alternativeName | Choi, Jae Yong | - |
dc.contributor.affiliatedAuthor | Lyoo, Chul Hyoung | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Jun | - |
dc.contributor.affiliatedAuthor | Ryu, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Myung Sik | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Cho, Hanna | - |
dc.contributor.affiliatedAuthor | Choi, Jae Yong | - |
dc.citation.volume | 59 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 120 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NUCLEAR MEDICINE, Vol.59(1) : 117-120, 2018 | - |
dc.identifier.rimsid | 59494 | - |
dc.type.rims | ART | - |
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