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The Effect of MMP-13, MMP-12, and AMBN on Gingival Enlargement and Root Deformation In a New Type of Gingival Fibromatosis

Authors
 Chung-Min Kang  ;  Jae-Ho Lee  ;  Mijeong Jeon  ;  Je Seon Song  ;  Seong-Oh Kim 
Citation
 Journal of Clinical Pediatric Dentistry, Vol.42(1) : 50-54, 2018 
Journal Title
 Journal of Clinical Pediatric Dentistry 
ISSN
 1053-4628 
Issue Date
2018
MeSH
Child ; Dental Enamel Proteins/*genetics ; Female ; Gingival/*genetics Fibromatosis ; Humans ; Matrix Metalloproteinase 12/*genetics ; Matrix Metalloproteinase 13/*genetics ; Oligonucleotide Array Sequence Analysis
Keywords
MMP-12 ; MMP-13 ; ameloblastin ; cDNA microarray ; gingival fibromatosis ; gingival overgrowth
Abstract
This case compared gene-expression between a new type of idiopathic gingival fibromatosis (IGF) and normal gingiva, to clarify the nature of the gingival overgrowth and dental anomaly. A 6-year-old girl with generalized gingival overgrowth and root deformations was diagnosed with IGF. Gene expression profiles were compared between normal gingiva (N=9) and one IGF gingiva using cDNA microarray. Genes related to regulation of cell proliferation and proteolytic degradation were expressed strongly in IGF. MMP-13 and MMP-12 expression were 120 times and 96 times lower in IGF, respectively, whereas AMBN expression was 79 times higher. RT-PCR and immunohistochemical staining supported the microarray results. Reduced proteolytic activity due to low MMP-13 and MMP-12 expression appears to be a potential mechanism for gingival overgrowth. Genetic investigations, such as expression levels of MMP-13, MMP-12, and AMBN, may enable classification of a new syndrome characterized by gingival enlargement with abnormal root development.
Full Text
http://jocpd.org/doi/10.17796/1053-4628-42.1.9?code=clpd-site
DOI
10.17796/1053-4628-42.1.9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
강정민(Kang, Chung Min) ORCID logo https://orcid.org/0000-0001-7813-3741
김성오(Kim, Seong Oh) ORCID logo https://orcid.org/0000-0002-8620-1377
송제선(Song, Je Seon) ORCID logo https://orcid.org/0000-0001-8620-5629
이제호(Lee, Jae Ho) ORCID logo https://orcid.org/0000-0002-1556-3485
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/161868
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