Cited 5 times in
The Effect of MMP-13, MMP-12, and AMBN on Gingival Enlargement and Root Deformation In a New Type of Gingival Fibromatosis
DC Field | Value | Language |
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dc.contributor.author | 강정민 | - |
dc.contributor.author | 김성오 | - |
dc.contributor.author | 송제선 | - |
dc.contributor.author | 이제호 | - |
dc.date.accessioned | 2018-08-28T16:43:07Z | - |
dc.date.available | 2018-08-28T16:43:07Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1053-4628 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/161868 | - |
dc.description.abstract | This case compared gene-expression between a new type of idiopathic gingival fibromatosis (IGF) and normal gingiva, to clarify the nature of the gingival overgrowth and dental anomaly. A 6-year-old girl with generalized gingival overgrowth and root deformations was diagnosed with IGF. Gene expression profiles were compared between normal gingiva (N=9) and one IGF gingiva using cDNA microarray. Genes related to regulation of cell proliferation and proteolytic degradation were expressed strongly in IGF. MMP-13 and MMP-12 expression were 120 times and 96 times lower in IGF, respectively, whereas AMBN expression was 79 times higher. RT-PCR and immunohistochemical staining supported the microarray results. Reduced proteolytic activity due to low MMP-13 and MMP-12 expression appears to be a potential mechanism for gingival overgrowth. Genetic investigations, such as expression levels of MMP-13, MMP-12, and AMBN, may enable classification of a new syndrome characterized by gingival enlargement with abnormal root development. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Journal of Pedodontics, Inc. | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL PEDIATRIC DENTISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Dental Enamel Proteins/*genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gingival/*genetics Fibromatosis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Matrix Metalloproteinase 12/*genetics | - |
dc.subject.MESH | Matrix Metalloproteinase 13/*genetics | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis | - |
dc.title | The Effect of MMP-13, MMP-12, and AMBN on Gingival Enlargement and Root Deformation In a New Type of Gingival Fibromatosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pharmacology | - |
dc.contributor.googleauthor | Chung-Min Kang | - |
dc.contributor.googleauthor | Jae-Ho Lee | - |
dc.contributor.googleauthor | Mijeong Jeon | - |
dc.contributor.googleauthor | Je Seon Song | - |
dc.contributor.googleauthor | Seong-Oh Kim | - |
dc.identifier.doi | 10.17796/1053-4628-42.1.9 | - |
dc.contributor.localId | A05078 | - |
dc.contributor.localId | A00577 | - |
dc.contributor.localId | A02058 | - |
dc.contributor.localId | A03134 | - |
dc.relation.journalcode | J01336 | - |
dc.identifier.eissn | 1557-5268 | - |
dc.identifier.pmid | 28937892 | - |
dc.identifier.url | http://jocpd.org/doi/10.17796/1053-4628-42.1.9?code=clpd-site | - |
dc.subject.keyword | MMP-12 | - |
dc.subject.keyword | MMP-13 | - |
dc.subject.keyword | ameloblastin | - |
dc.subject.keyword | cDNA microarray | - |
dc.subject.keyword | gingival fibromatosis | - |
dc.subject.keyword | gingival overgrowth | - |
dc.contributor.alternativeName | Kang, Chung Min | - |
dc.contributor.alternativeName | Kim, Seong Oh | - |
dc.contributor.alternativeName | Song, Je Seon | - |
dc.contributor.alternativeName | Lee, Jae Ho | - |
dc.contributor.affiliatedAuthor | Kang, Chung Min | - |
dc.contributor.affiliatedAuthor | Kim, Seong Oh | - |
dc.contributor.affiliatedAuthor | Song, Je Seon | - |
dc.contributor.affiliatedAuthor | Lee, Jae Ho | - |
dc.citation.volume | 42 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 50 | - |
dc.citation.endPage | 54 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL PEDIATRIC DENTISTRY, Vol.42(1) : 50-54, 2018 | - |
dc.identifier.rimsid | 59460 | - |
dc.type.rims | ART | - |
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