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Usefulness of the delta neutrophil index to predict 30-day mortality in patients with ST segment elevation myocardial infarction

Authors
 Taeyoung Kong  ;  Tae Hoon Kim  ;  Yoo Seok Park  ;  Sung Phil Chung  ;  Hye Sun Lee  ;  Jung Hwa Hong  ;  Jong Wook Lee  ;  Je Sung You  ;  Incheol Park 
Citation
 Scientific Reports, Vol.7(1) : 15718, 2017 
Journal Title
 Scientific Reports 
Issue Date
2017
Abstract
This study aimed to evaluate the association between the delta neutrophil index (DNI), which reflects immature granulocytes, and the severity of ST-elevation myocardial infarction (STEMI), as well as to determine the significance of the DNI as a prognostic marker for early mortality and other clinical outcomes in patients with STEMI who underwent reperfusion. This retrospective, observational cohort study was conducted using patients prospectively integrated in a critical pathway program for STEMI. We included 842 patients diagnosed with STEMI who underwent primary percutaneous coronary intervention (pPCI). Higher DNI values at time-I (within 2 h of pPCI; hazard ratio [HR], 1.075; 95% confidence interval [CI]: 1.046-1.108; p < 0.001) and time-24 (24 h after admission; HR, 1.066; 95% CI: 1.045-1.086; p < 0.001) were significant independent risk factors for 30-day mortality. Specifically, DNI values >2.5% at time-I (HR, 13.643; 95% CI: 8.13-22.897; p < 0.001) and > 2.9% at time-24 (HR, 12.752; 95% CI: 7.308-22.252; p < 0.001) associated with increased risks of 30-day mortality. In conclusion, an increased DNI value, which reflects the proportion of circulating immature granulocytes in the blood, was found to be an independent predictor of 30-day mortality and poor clinical outcomes in patients with acute STEMI post-pPCI.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161333
DOI
10.1038/s41598-017-15878-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
공태영(Kong, Tae Young)
김태훈(Kim, Tae-Hoon)
박유석(Park, Yoo Seok)
박인철(Park, In Cheol)
유제성(You, Je Sung)
이혜선(Lee, Hye Sun)
정성필(Chung, Sung Pil)
홍정화(Hong, Jung Hwa)
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