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The pulvinar nucleus is associated with the presence of dysarthria in patients with basal ganglia hemorrhage

Authors
 Dae Hyun Kim  ;  Sunghyon Kyeong  ;  Sung Jun Ahn  ;  Yoon Ghil Park 
Citation
 Neuroscience Letters, Vol.655 : 131-136, 2017 
Journal Title
 Neuroscience Letters 
ISSN
 0304-3940 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; Basal Ganglia Hemorrhage/pathology ; Basal Ganglia Hemorrhage/physiopathology ; Brain Mapping ; Dysarthria/pathology ; Dysarthria/physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pulvinar/pathology ; Retrospective Studies
Keywords
Basal ganglia hemorrhage ; Cerebral hemorrhage ; Dysarthria ; Stroke ; Thalamus
Abstract
Dysarthria is a frequent symptom in patients with stroke. The anatomical structures responsible for dysarthria have been reported in patients with lacunar infarcts, but the related lesions in patients with basal ganglia hemorrhage (BGH) have not been investigated. The aim of this study was to identify associations between the lesion location and the presence/absence of dysarthria in patients with BGH using voxel-based lesion symptom mapping (VLSM) analyses. A retrospective analysis was conducted on 26 patients with acute BGH (mean age, 54.0 years; men:women, 14:12) who underwent conservative management. The patients were classified into groups based on the presence or absence of dysarthria at the time of admission, which was determined by reviewing the patients' medical records. Brain lesions were traced on magnetic resonance images that were acquired within the first 3 weeks after BGH onset, and then separate high-resolution region-of-interest images were generated. Associations between dysarthria and the lesion location were determined with the VLSM analyses. The average volume of the delimited lesions was 7.38±5.75cm3. The VLSM analyses identified several voxel clusters, mainly in the pulvinar nucleus of the left thalamus, that were significantly related to the presence of dysarthria at admission. These findings suggest that patients with BGH extending into the left pulvinar nucleus should be monitored for dysarthria.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/161175
DOI
10.1016/j.neulet.2017.07.002
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
경성현(Kyeong, Sung Hyon) ; 박윤길(Park, Yoon Ghil) ; 안성준(Ahn, Sung Jun)
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Full Text
https://www.sciencedirect.com/science/article/pii/S0304394017305530
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