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Chronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice

 Hyung-Ju Cho  ;  Woon Heo  ;  Jung Woo Han  ;  Yong Hyuk Lee  ;  Jin Myung Park  ;  Min Jung Kang  ;  Joo-Heon Yoon  ;  Min Goo Lee  ;  Chang-Hoon Kim  ;  Joo Young Kim 
 SLEEP , Vol.40(8) : zsx103, 2017 
Journal Title
Issue Date
Animals ; Chronic Disease ; Disease Models, Animal ; Endothelins/metabolism ; Heart Ventricles/pathology* ; Hypoxia/pathology* ; Lung/blood supply ; Male ; Mice ; Mice, Inbred C57BL ; Muscle Cells/metabolism ; Muscle Cells/pathology ; Sleep Apnea, Obstructive/metabolism ; Sleep Apnea, Obstructive/pathology
cine-MRI ; endothelin ; mouse ; pulmonary hypertension ; right ventricle ; sleep apnea
Study Objective: No studies have investigated sequential changes in the heart on magnetic resonance imaging (MRI), along with observation of functional lung phenotypes and genetics, over the duration of chronic intermittent hypoxia (CIH). We investigated chronological changes in heart and lung phenotypes after CIH using a mouse model to provide new insights into the pathophysiology of sleep apnea-induced cardiovascular disease.

Methods: C57BL/6J adult male mice were randomized to 4 or 8 weeks of CIH. Cardiac cine-MRI images were analyzed to assess functional parameters of right ventricle (RV). Histopathological features of myocytes and pulmonary vessels, as well as genes involved in the endothelin (ET) system, were investigated.

Results: Function of the RV reduced significantly at 4 weeks and continuously decreased following another 4 weeks of CIH, although the rate of decrease was attenuated. Notably, persistence of reduced ejection fraction and end-systole RV wall thickness (WT) and increases in the ET system of the lungs and blood strongly implied the development of pulmonary hypertension after 8 weeks of CIH.

Conclusions: RV dysfunction with reduced end-systole RV WT could be a late phenotype in long-standing CIH and possibly also in obstructive sleep apnea.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Young(김주영) ORCID logo https://orcid.org/0000-0003-2623-1491
Kim, Chang Hoon(김창훈) ORCID logo https://orcid.org/0000-0003-1238-6396
Yoon, Joo Heon(윤주헌)
Lee, Min Goo(이민구) ORCID logo https://orcid.org/0000-0001-7436-012X
Cho, Hyung Ju(조형주) ORCID logo https://orcid.org/0000-0002-2851-3225
Han, Jung Woo(한정우)
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