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Cited 3 times in

Chronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice

DC Field Value Language
dc.contributor.author김주영-
dc.contributor.author김창훈-
dc.contributor.author윤주헌-
dc.contributor.author이민구-
dc.contributor.author조형주-
dc.contributor.author한정우-
dc.date.accessioned2018-07-20T08:21:16Z-
dc.date.available2018-07-20T08:21:16Z-
dc.date.issued2017-
dc.identifier.issn0161-8105-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/161115-
dc.description.abstractStudy Objective: No studies have investigated sequential changes in the heart on magnetic resonance imaging (MRI), along with observation of functional lung phenotypes and genetics, over the duration of chronic intermittent hypoxia (CIH). We investigated chronological changes in heart and lung phenotypes after CIH using a mouse model to provide new insights into the pathophysiology of sleep apnea-induced cardiovascular disease. Methods: C57BL/6J adult male mice were randomized to 4 or 8 weeks of CIH. Cardiac cine-MRI images were analyzed to assess functional parameters of right ventricle (RV). Histopathological features of myocytes and pulmonary vessels, as well as genes involved in the endothelin (ET) system, were investigated. Results: Function of the RV reduced significantly at 4 weeks and continuously decreased following another 4 weeks of CIH, although the rate of decrease was attenuated. Notably, persistence of reduced ejection fraction and end-systole RV wall thickness (WT) and increases in the ET system of the lungs and blood strongly implied the development of pulmonary hypertension after 8 weeks of CIH. Conclusions: RV dysfunction with reduced end-systole RV WT could be a late phenotype in long-standing CIH and possibly also in obstructive sleep apnea.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAssociated Professional Sleep Societies-
dc.relation.isPartOfSLEEP-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHChronic Disease-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHEndothelins/metabolism-
dc.subject.MESHHeart Ventricles/pathology*-
dc.subject.MESHHypoxia/pathology*-
dc.subject.MESHLung/blood supply-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMuscle Cells/metabolism-
dc.subject.MESHMuscle Cells/pathology-
dc.subject.MESHSleep Apnea, Obstructive/metabolism-
dc.subject.MESHSleep Apnea, Obstructive/pathology-
dc.titleChronological Change of Right Ventricle by Chronic Intermittent Hypoxia in Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pharmacology-
dc.contributor.googleauthorHyung-Ju Cho-
dc.contributor.googleauthorWoon Heo-
dc.contributor.googleauthorJung Woo Han-
dc.contributor.googleauthorYong Hyuk Lee-
dc.contributor.googleauthorJin Myung Park-
dc.contributor.googleauthorMin Jung Kang-
dc.contributor.googleauthorJoo-Heon Yoon-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorChang-Hoon Kim-
dc.contributor.googleauthorJoo Young Kim-
dc.identifier.doi10.1093/sleep/zsx103-
dc.contributor.localIdA00942-
dc.contributor.localIdA01050-
dc.contributor.localIdA02604-
dc.contributor.localIdA02781-
dc.contributor.localIdA03936-
dc.contributor.localIdA05439-
dc.relation.journalcodeJ02661-
dc.identifier.eissn1550-9109-
dc.identifier.pmid28637196-
dc.identifier.urlhttps://academic.oup.com/sleep/article/40/8/zsx103/3872269-
dc.subject.keywordcine-MRI-
dc.subject.keywordendothelin-
dc.subject.keywordmouse-
dc.subject.keywordpulmonary hypertension-
dc.subject.keywordright ventricle-
dc.subject.keywordsleep apnea-
dc.contributor.alternativeNameKim, Joo Young-
dc.contributor.alternativeNameKim, Chang Hoon-
dc.contributor.alternativeNameYoon, Joo Heon-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.alternativeNameCho, Hyung Ju-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorKim, Joo Young-
dc.contributor.affiliatedAuthorKim, Chang Hoon-
dc.contributor.affiliatedAuthorYoon, Joo Heon-
dc.contributor.affiliatedAuthorLee, Min Goo-
dc.contributor.affiliatedAuthorCho, Hyung Ju-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.citation.volume40-
dc.citation.number8-
dc.citation.startPagezsx103-
dc.identifier.bibliographicCitationSLEEP , Vol.40(8) : zsx103, 2017-
dc.identifier.rimsid61004-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers

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