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Analysis of structure-function network decoupling in the brain systems of spastic diplegic cerebral palsy

Authors
 Dongha Lee  ;  Chongwon Pae  ;  Jong Doo Lee  ;  Eun Sook Park  ;  Sung‐Rae Cho  ;  Min‐Hee Um  ;  Seung‐Koo Lee  ;  Maeng‐Keun Oh  ;  Hae‐Jeong Park 
Citation
 Human Brain Mapping, Vol.38(10) : 5292-5306, 2017 
Journal Title
 Human Brain Mapping 
ISSN
 1065-9471 
Issue Date
2017
Keywords
brain network ; cerebral palsy ; functional reorganization ; structure-function relationship
Abstract
Manifestation of the functionalities from the structural brain network is becoming increasingly important to understand a brain disease. With the aim of investigating the differential structure-function couplings according to network systems, we investigated the structural and functional brain networks of patients with spastic diplegic cerebral palsy with periventricular leukomalacia compared to healthy controls. The structural and functional networks of the whole brain and motor system, constructed using deterministic and probabilistic tractography of diffusion tensor magnetic resonance images and Pearson and partial correlation analyses of resting-state functional magnetic resonance images, showed differential embedding of functional networks in the structural networks in patients. In the whole-brain network of patients, significantly reduced global network efficiency compared to healthy controls were found in the structural networks but not in the functional networks, resulting in reduced structural-functional coupling. On the contrary, the motor network of patients had a significantly lower functional network efficiency over the intact structural network and a lower structure-function coupling than the control group. This reduced coupling but reverse directionality in the whole-brain and motor networks of patients was prominent particularly between the probabilistic structural and partial correlation-based functional networks. Intact (or less deficient) functional network over impaired structural networks of the whole brain and highly impaired functional network topology over the intact structural motor network might subserve relatively preserved cognitions and impaired motor functions in cerebral palsy. This study suggests that the structure-function relationship, evaluated specifically using sparse functional connectivity, may reveal important clues to functional reorganization in cerebral palsy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/160909
DOI
10.1002/hbm.23738
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)
Yonsei Authors
박은숙(Park, Eun Sook)
박해정(Park, Hae Jeong)
오맹근(Oh, Maeng Keun)
이승구(Lee, Seung Koo)
조성래(Cho, Sung Rae)
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Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.23738
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