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Localization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23

 Ji-Yeon Lee  ;  Hye-Sun Park  ;  Seunghee Han  ;  Jiyu Kelly Lim  ;  Namki Hong  ;  Sung Il Park  ;  Yumie Rhee 
 YONSEI MEDICAL JOURNAL, Vol.58(5) : 981-987, 2017 
Journal Title
Issue Date
Adolescent ; Adult ; Fibroblast Growth Factors/blood* ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neoplasms, Connective Tissue/blood* ; Neoplasms, Connective Tissue/diagnostic imaging ; Neoplasms, Connective Tissue/pathology* ; Octreotide/analogs & derivatives ; Octreotide/chemistry ; Organometallic Compounds/chemistry ; Veins/pathology* ; Young Adult
Tumor-induced osteomalacia ; fibroblast growth factor 23 ; venous sampling
PURPOSE: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients. MATERIALS AND METHODS: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed. Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies. RESULTS: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling, and in two patients, the lesions were detected after 3 years by means of ⁶⁸Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging. CONCLUSION: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Sung Il(박성일)
Park, Hye Sun(박혜선)
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Ji Yeon(이지연)
Han, Seung Hee(한승희)
Hong, Nam Ki(홍남기) ORCID logo https://orcid.org/0000-0002-8246-1956
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