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Localization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23

DC Field Value Language
dc.contributor.author박성일-
dc.contributor.author박혜선-
dc.contributor.author이유미-
dc.contributor.author이지연-
dc.contributor.author한승희-
dc.contributor.author홍남기-
dc.date.accessioned2018-07-20T07:57:45Z-
dc.date.available2018-07-20T07:57:45Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160710-
dc.description.abstractPURPOSE: Tumor-induced osteomalacia (TIO) is characterized by hypophosphatemia caused by a phosphaturic mesenchymal tumor. While surgical resection of the tumor leads to a cure, identification of the responsible tumor is challenging. Recently, several studies showed that systemic sampling of fibroblast growth factor 23 (FGF23) is helpful for localization of tumors. The present study aimed to evaluate the clinical utility of this method in Korean patients. MATERIALS AND METHODS: Six patients compatible with TIO who were admitted to our hospital between 2006 and 2015 were analyzed. Systemic venous sampling of FGF23 was performed to detect blind lesions or to confirm a suspicious lesion identified in previous imaging studies. RESULTS: Venous sampling helped confirming the tumor in five of the six patients. Three patients underwent surgery after sampling, and in two patients, the lesions were detected after 3 years by means of ⁶⁸Ga-DOTATOC positron emission tomography with computed tomography. In one patient, there was a local elevation of serum FGF23 without any related lesion on additional imaging. CONCLUSION: Our data strengthened the value of venous sampling of FGF23 in predicting the location of tumors and suggested that it can be more effective in the presence of the relevant lesion in subsequent imaging analyses.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHFibroblast Growth Factors/blood*-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms, Connective Tissue/blood*-
dc.subject.MESHNeoplasms, Connective Tissue/diagnostic imaging-
dc.subject.MESHNeoplasms, Connective Tissue/pathology*-
dc.subject.MESHOctreotide/analogs & derivatives-
dc.subject.MESHOctreotide/chemistry-
dc.subject.MESHOrganometallic Compounds/chemistry-
dc.subject.MESHVeins/pathology*-
dc.subject.MESHYoung Adult-
dc.titleLocalization of oncogenic osteomalacia by systemic venous sampling of fibroblast growth factor 23-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorJi-Yeon Lee-
dc.contributor.googleauthorHye-Sun Park-
dc.contributor.googleauthorSeunghee Han-
dc.contributor.googleauthorJiyu Kelly Lim-
dc.contributor.googleauthorNamki Hong-
dc.contributor.googleauthorSung Il Park-
dc.contributor.googleauthorYumie Rhee-
dc.identifier.doi10.3349/ymj.2017.58.5.981-
dc.contributor.localIdA01510-
dc.contributor.localIdA01761-
dc.contributor.localIdA03012-
dc.contributor.localIdA03197-
dc.contributor.localIdA04306-
dc.contributor.localIdA04388-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid28792142-
dc.subject.keywordTumor-induced osteomalacia-
dc.subject.keywordfibroblast growth factor 23-
dc.subject.keywordvenous sampling-
dc.contributor.alternativeNamePark, Sung Il-
dc.contributor.alternativeNamePark, Hye Sun-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLee, Ji Yeon-
dc.contributor.alternativeNameHan, Seung Hee-
dc.contributor.alternativeNameHong, Nam Ki-
dc.contributor.affiliatedAuthorPark, Sung Il-
dc.contributor.affiliatedAuthorPark, Hye Sun-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.contributor.affiliatedAuthorLee, Ji Yeon-
dc.contributor.affiliatedAuthorHan, Seung Hee-
dc.contributor.affiliatedAuthorHong, Namki-
dc.citation.volume58-
dc.citation.number5-
dc.citation.startPage981-
dc.citation.endPage987-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(5) : 981-987, 2017-
dc.identifier.rimsid43773-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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