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Functional connectivity of the circadian clock and neural substrates of sleep-wake disturbance in delirium

Authors
 Sunghyon Kyeong  ;  Soo-Hee Choi  ;  Jung Eun Shin  ;  Woo Suk Lee  ;  Kyu Hyun Yang  ;  Tae-Sub Chung  ;  Jae-Jin Kim 
Citation
 PSYCHIATRY RESEARCH, Vol.264 : 10-12, 2017 
Journal Title
 PSYCHIATRY RESEARCH 
ISSN
 0165-1781 
Issue Date
2017
MeSH
Aged ; Aged, 80 and over ; Cerebral Cortex/diagnostic imaging* ; Cerebral Cortex/physiopathology ; Circadian Clocks/physiology* ; Circadian Rhythm/physiology ; Delirium/diagnostic imaging* ; Delirium/physiopathology ; Delirium/psychology ; Female ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/physiopathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Nerve Net/diagnostic imaging* ; Nerve Net/physiopathology ; Sleep Disorders, Circadian Rhythm/diagnostic imaging* ; Sleep Disorders, Circadian Rhythm/physiopathology ; Thalamus/diagnostic imaging* ; Thalamus/physiopathology
Keywords
Delirium ; Functional connectivity ; Suprachiasmatic nucleus
Abstract
A possible mechanism of disrupted circadian rhythms in delirium was identified using resting-state functional connectivity. Thirty-four delirious patients and 38 non-delirious controls were scanned for resting-state functional MRI. Seed-based connectivity of the suprachiasmatic nucleus was compared between the groups. In delirious patients functional connectivity from the circadian clock was increased to the dorsal anterior cingulate cortex and decreased to the posterior cingulate cortex, parahippocampal gyrus, cerebellum, and thalamus. A dysregulation of the default mode network and mental coordination processing areas by the circadian clock may be the underlying pathophysiology of sleep-wake cycle disturbance and symptom fluctuation in delirium.
Full Text
https://www.sciencedirect.com/science/article/pii/S0925492716303389
DOI
10.1016/j.pscychresns.2017.03.017
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kyeong, Sung Hyon(경성현)
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Yang, Kyu Hyun(양규현) ORCID logo https://orcid.org/0000-0001-7183-588X
Lee, Woo Suk(이우석) ORCID logo https://orcid.org/0000-0002-0798-1660
Chung, Tae Sub(정태섭)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160368
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