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Leiomyosarcoma: investigation of prognostic factors for risk-stratification model

Authors
 Hyun Ju Kim  ;  Yong Jin Cho  ;  Soo Hee Kim  ;  Sun Young Rha  ;  Joong Bae Ahn  ;  Woo Ick Yang  ;  Young Han Lee  ;  Jin‑Suck Suh  ;  Jae Kyung Roh  ;  Kyung Sik Kim  ;  Young Deuk Choi  ;  Kyoo‑Ho Shin  ;  Hyo Song Kim 
Citation
 International Journal of Clinical Oncology, Vol.20(6) : 1226-1232, 2015 
Journal Title
 International Journal of Clinical Oncology 
ISSN
 1341-9625 
Issue Date
2015
MeSH
Adult ; Aged ; Aged, 80 and over ; Extremities ; Female ; Head and Neck Neoplasms/pathology* ; Head and Neck Neoplasms/surgery* ; Humans ; Leiomyosarcoma/pathology* ; Leiomyosarcoma/surgery* ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm, Residual ; Pelvic Neoplasms/pathology* ; Pelvic Neoplasms/surgery* ; Prognosis ; Proportional Hazards Models ; Retroperitoneal Neoplasms/pathology* ; Retroperitoneal Neoplasms/surgery* ; Retrospective Studies ; Risk Assessment ; Survival Rate ; Thoracic Neoplasms/pathology* ; Thoracic Neoplasms/surgery* ; Tumor Burden ; Young Adult
Keywords
Leiomyosarcoma ; Prognostic factors ; Risk stratification model
Abstract
BACKGROUND: We performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors. METHODS: Between 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed. RESULTS: Of the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n = 25), pelvis (n = 40), thoracic cavity (n = 11), intra-abdomen (n = 19), retroperitoneum (n = 23), and head/neck (n = 11). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n = 42) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n = 87). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0 years, P = 0.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P = 0.027). Independent prognostic factors for survival were primary site (P = 0.041, hazard ratio (HR) 1.7; 95 % CI 1.2-2.8), tumor size (P = 0.038, HR 1.9; 95 % CI 1.13-3.38), margin status (P = 0.019, HR 2.1; 95 % CI 1.13-3.88), and histology grade (P = 0.01, HR 3.59; 95 % CI 1.64-7.87). We identified four different risk groups with different survival outcome: group 1 (n = 8), no adverse factors; groups 2 (n = 37) and 3 (n = 61) with one and two adverse factors, and group 4 (n = 23) with 3 or 4 adverse factors. CONCLUSION: Primary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination.
Full Text
https://link.springer.com/article/10.1007%2Fs10147-015-0847-y
DOI
10.1007/s10147-015-0847-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
김경식(Kim, Kyung Sik) ORCID logo https://orcid.org/0000-0001-9498-284X
김수희(Kim, Soo Hee)
김현주(Kim, Hyun Ju)
김효송(Kim, Hyo Song) ORCID logo https://orcid.org/0000-0002-0625-9828
노재경(Roh, Jae Kyung)
라선영(Rha, Sun Young) ORCID logo https://orcid.org/0000-0002-2512-4531
서진석(Suh, Jin Suck) ORCID logo https://orcid.org/0000-0001-9455-9240
신규호(Shin, Kyoo Ho)
안중배(Ahn, Joong Bae) ORCID logo https://orcid.org/0000-0001-6787-1503
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
이영한(Lee, Young Han) ORCID logo https://orcid.org/0000-0002-5602-391X
조영진(Cho, Yong Jin)
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156812
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