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Leiomyosarcoma: investigation of prognostic factors for risk-stratification model

DC Field Value Language
dc.contributor.author김경식-
dc.contributor.author김수희-
dc.contributor.author김현주-
dc.contributor.author김효송-
dc.contributor.author노재경-
dc.contributor.author라선영-
dc.contributor.author서진석-
dc.contributor.author신규호-
dc.contributor.author안중배-
dc.contributor.author양우익-
dc.contributor.author이영한-
dc.contributor.author조영진-
dc.contributor.author최영득-
dc.date.accessioned2018-03-26T16:46:52Z-
dc.date.available2018-03-26T16:46:52Z-
dc.date.issued2015-
dc.identifier.issn1341-9625-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156812-
dc.description.abstractBACKGROUND: We performed this study to define distinctive clinical features of leiomyosarcoma by assessing prognostic factors. METHODS: Between 1988 and 2011, 129 leiomyosarcoma patients who underwent surgical resection with curative intent were retrospectively reviewed. RESULTS: Of the 129 leiomyosarcoma patients, the distribution of anatomic locations was: extremity (n = 25), pelvis (n = 40), thoracic cavity (n = 11), intra-abdomen (n = 19), retroperitoneum (n = 23), and head/neck (n = 11). We classified the anatomic locations into two categories as abdominal (intra-abdomen and retroperitoneum, n = 42) and extra-abdominal (extremity, pelvis, thoracic cavity, and head/neck, n = 87). Prognosis was worse for the abdominal group than for the extra-abdominal group (median DFS 2.9 9.0 years, P = 0.04). Similarly, overall survival (OS) was also significantly worse for abdominal group (P = 0.027). Independent prognostic factors for survival were primary site (P = 0.041, hazard ratio (HR) 1.7; 95 % CI 1.2-2.8), tumor size (P = 0.038, HR 1.9; 95 % CI 1.13-3.38), margin status (P = 0.019, HR 2.1; 95 % CI 1.13-3.88), and histology grade (P = 0.01, HR 3.59; 95 % CI 1.64-7.87). We identified four different risk groups with different survival outcome: group 1 (n = 8), no adverse factors; groups 2 (n = 37) and 3 (n = 61) with one and two adverse factors, and group 4 (n = 23) with 3 or 4 adverse factors. CONCLUSION: Primary site, tumor size, resection margin, and histology subtype were independently associated with survival outcome. A prognostic model for leiomyosarcoma patients revealed four distinct groups of patients with good prognostic discrimination.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag Tokyo-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHExtremities-
dc.subject.MESHFemale-
dc.subject.MESHHead and Neck Neoplasms/pathology*-
dc.subject.MESHHead and Neck Neoplasms/surgery*-
dc.subject.MESHHumans-
dc.subject.MESHLeiomyosarcoma/pathology*-
dc.subject.MESHLeiomyosarcoma/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeoplasm, Residual-
dc.subject.MESHPelvic Neoplasms/pathology*-
dc.subject.MESHPelvic Neoplasms/surgery*-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetroperitoneal Neoplasms/pathology*-
dc.subject.MESHRetroperitoneal Neoplasms/surgery*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHSurvival Rate-
dc.subject.MESHThoracic Neoplasms/pathology*-
dc.subject.MESHThoracic Neoplasms/surgery*-
dc.subject.MESHTumor Burden-
dc.subject.MESHYoung Adult-
dc.titleLeiomyosarcoma: investigation of prognostic factors for risk-stratification model-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorHyun Ju Kim-
dc.contributor.googleauthorYong Jin Cho-
dc.contributor.googleauthorSoo Hee Kim-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorWoo Ick Yang-
dc.contributor.googleauthorYoung Han Lee-
dc.contributor.googleauthorJin‑Suck Suh-
dc.contributor.googleauthorJae Kyung Roh-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorKyoo‑Ho Shin-
dc.contributor.googleauthorHyo Song Kim-
dc.identifier.doi10.1007/s10147-015-0847-y-
dc.contributor.localIdA00299-
dc.contributor.localIdA00644-
dc.contributor.localIdA01136-
dc.contributor.localIdA01202-
dc.contributor.localIdA01290-
dc.contributor.localIdA01316-
dc.contributor.localIdA01916-
dc.contributor.localIdA02086-
dc.contributor.localIdA02262-
dc.contributor.localIdA02300-
dc.contributor.localIdA02967-
dc.contributor.localIdA03860-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ01097-
dc.identifier.eissn1437-7772-
dc.identifier.pmid26123311-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10147-015-0847-y-
dc.subject.keywordLeiomyosarcoma-
dc.subject.keywordPrognostic factors-
dc.subject.keywordRisk stratification model-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameKim, Soo Hee-
dc.contributor.alternativeNameKim, Hyun Ju-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameRoh, Jae Kyung-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameShin, Kyoo Ho-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameYang, Woo Ick-
dc.contributor.alternativeNameLee, Young Han-
dc.contributor.alternativeNameCho, Yong Jin-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorKim, Soo Hee-
dc.contributor.affiliatedAuthorKim, Hyun Ju-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorRoh, Jae Kyung-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorShin, Kyoo Ho-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorYang, Woo Ick-
dc.contributor.affiliatedAuthorLee, Young Han-
dc.contributor.affiliatedAuthorCho, Yong Jin-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.citation.volume20-
dc.citation.number6-
dc.citation.startPage1226-
dc.citation.endPage1232-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, Vol.20(6) : 1226-1232, 2015-
dc.identifier.rimsid39940-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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