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The Effect of Red Ginseng Extract Intake on Ischemic Flaps

 In Sik Yun  ;  Young Seok Kim  ;  Tai Suk Roh  ;  Won Jai Lee  ;  Tae Hwan Park  ;  Hyun Roh  ;  Dae Hyun Lew  ;  Dong Kyun Rah 
 Journal of Investigative Surgery, Vol.30(1) : 19-25, 2017 
Journal Title
 Journal of Investigative Surgery 
Issue Date
Administration, Oral ; Animals ; Disease Models, Animal ; Graft Survival/drug effects* ; Immunohistochemistry ; Male ; Neovascularization, Physiologic/drug effects* ; Panax/chemistry* ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacology* ; Plant Roots ; Platelet Endothelial Cell Adhesion Molecule-1/metabolism ; Rats ; Rats, Sprague-Dawley ; Regional Blood Flow/drug effects* ; Surgical Flaps/blood supply* ; Vascular Endothelial Growth Factor A/metabolism*
angiogenesis-inducing agents ; blood flow ; ischemic disease ; panax ; surgical flaps ; vascular endothelial growth factor A
Red ginseng is well known for its angiogenic effects and its effect of increasing expression of vascular endothelial growth factors (VEGFs), but little experimental evidence has been published. In this study, we examined the effect of red ginseng using an ischemic flap model. Twenty male Sprague-Dawley rats were divided into two groups of 10. One group drank red ginseng solution from 7 days prior to surgery to 7 days after, whereas the other group drank distilled water. We created a local flap on the back of each rat. We analyzed the surviving area of the flap for 10 days after surgery and measured the blood flow of the flap. Ten days after the operation, CD31-positive vessels and VEGF expression were examined by immunohistochemistry. The percentages of surviving areas of the flap were 76 ± 3% for the experimental group and 39 ± 5% for the control group (P = 0.0002). Blood flow in the experimental group increased for 10 days after the surgery. The number of newly generated capillaries in the experimental group was 14.0 ± 3.5, which was significantly higher than 5.7 ± 1.9 in the control group. The expression of VEGF in the experimental group was significantly higher than in the control group (p = 0.0003). Administration of red ginseng extract increases the survival of ischemic flaps via angiogenesis and elevated blood flow. Further clinical studies are warranted to apply the effect shown in this current investigation to various ischemic conditions.
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1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
김영석(Kim, Young Seok) ORCID logo https://orcid.org/0000-0002-0981-2107
나동균(Rah, Dong Kyun)
노태석(Roh, Tai Suk) ORCID logo https://orcid.org/0000-0001-8681-159X
박태환(Park, Tae Hwan)
유대현(Lew, Dae Hyun)
윤인식(Yun, In Sik) ORCID logo https://orcid.org/0000-0003-1103-7047
이원재(Lee, Won Jai) ORCID logo https://orcid.org/0000-0003-3056-0503
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