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The Effect of Red Ginseng Extract Intake on Ischemic Flaps

DC FieldValueLanguage
dc.contributor.author김영석-
dc.contributor.author노태석-
dc.contributor.author박태환-
dc.contributor.author유대현-
dc.contributor.author윤인식-
dc.contributor.author이원재-
dc.contributor.author나동균-
dc.date.accessioned2017-11-02T08:39:22Z-
dc.date.available2017-11-02T08:39:22Z-
dc.date.issued2017-
dc.identifier.issn0894-1939-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154724-
dc.description.abstractRed ginseng is well known for its angiogenic effects and its effect of increasing expression of vascular endothelial growth factors (VEGFs), but little experimental evidence has been published. In this study, we examined the effect of red ginseng using an ischemic flap model. Twenty male Sprague-Dawley rats were divided into two groups of 10. One group drank red ginseng solution from 7 days prior to surgery to 7 days after, whereas the other group drank distilled water. We created a local flap on the back of each rat. We analyzed the surviving area of the flap for 10 days after surgery and measured the blood flow of the flap. Ten days after the operation, CD31-positive vessels and VEGF expression were examined by immunohistochemistry. The percentages of surviving areas of the flap were 76 ± 3% for the experimental group and 39 ± 5% for the control group (P = 0.0002). Blood flow in the experimental group increased for 10 days after the surgery. The number of newly generated capillaries in the experimental group was 14.0 ± 3.5, which was significantly higher than 5.7 ± 1.9 in the control group. The expression of VEGF in the experimental group was significantly higher than in the control group (p = 0.0003). Administration of red ginseng extract increases the survival of ischemic flaps via angiogenesis and elevated blood flow. Further clinical studies are warranted to apply the effect shown in this current investigation to various ischemic conditions.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherInforma Healthcare-
dc.relation.isPartOfJournal of Investigative Surgery-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAnimals-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHGraft Survival/drug effects*-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHNeovascularization, Physiologic/drug effects*-
dc.subject.MESHPanax/chemistry*-
dc.subject.MESHPlant Extracts/administration & dosage-
dc.subject.MESHPlant Extracts/pharmacology*-
dc.subject.MESHPlant Roots-
dc.subject.MESHPlatelet Endothelial Cell Adhesion Molecule-1/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHRegional Blood Flow/drug effects*-
dc.subject.MESHSurgical Flaps/blood supply*-
dc.subject.MESHVascular Endothelial Growth Factor A/metabolism*-
dc.titleThe Effect of Red Ginseng Extract Intake on Ischemic Flaps-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Plastic Surgery & Reconstructive Surgery-
dc.contributor.googleauthorIn Sik Yun-
dc.contributor.googleauthorYoung Seok Kim-
dc.contributor.googleauthorTai Suk Roh-
dc.contributor.googleauthorWon Jai Lee-
dc.contributor.googleauthorTae Hwan Park-
dc.contributor.googleauthorHyun Roh-
dc.contributor.googleauthorDae Hyun Lew-
dc.contributor.googleauthorDong Kyun Rah-
dc.identifier.doi10.1080/08941939.2016.1215577-
dc.contributor.localIdA01297-
dc.contributor.localIdA04944-
dc.contributor.localIdA02459-
dc.contributor.localIdA02588-
dc.contributor.localIdA03005-
dc.contributor.localIdA01229-
dc.contributor.localIdA00709-
dc.relation.journalcodeJ01471-
dc.identifier.pmid27537618-
dc.identifier.urlhttp://www.tandfonline.com/doi/full/10.1080/08941939.2016.1215577-
dc.subject.keywordangiogenesis-inducing agents-
dc.subject.keywordblood flow-
dc.subject.keywordischemic disease-
dc.subject.keywordpanax-
dc.subject.keywordsurgical flaps-
dc.subject.keywordvascular endothelial growth factor A-
dc.contributor.alternativeNameKim, Young Seok-
dc.contributor.alternativeNameRoh, Tai Suk-
dc.contributor.alternativeNamePark, Tae Hwan-
dc.contributor.alternativeNameLew, Dae Hyun-
dc.contributor.alternativeNameYun, In Sik-
dc.contributor.alternativeNameLee, Won Jai-
dc.contributor.alternativeNameRah, Dong Kyun-
dc.contributor.affiliatedAuthorRoh, Tai Suk-
dc.contributor.affiliatedAuthorPark, Tae Hwan-
dc.contributor.affiliatedAuthorLew, Dae Hyun-
dc.contributor.affiliatedAuthorYun, In Sik-
dc.contributor.affiliatedAuthorLee, Won Jai-
dc.contributor.affiliatedAuthorRah, Dong Kyun-
dc.contributor.affiliatedAuthorKim, Young Seok-
dc.citation.titleJournal of Investigative Surgery-
dc.citation.volume30-
dc.citation.number1-
dc.citation.startPage19-
dc.citation.endPage25-
dc.identifier.bibliographicCitationJournal of Investigative Surgery, Vol.30(1) : 19-25, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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