72 123

Cited 0 times in

Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study

Authors
 Bok Ki Jung  ;  Won Jai Lee  ;  Eunhye Kang  ;  Hyo Min Ahn  ;  Yong Oock Kim  ;  Dong Kyun Rah  ;  Chae-Ok Yun  ;  In Sik Yun 
Citation
 Archives of Craniofacial Surgery, Vol.18(1) : 9-15, 2017 
Journal Title
 Archives of Craniofacial Surgery 
ISSN
 2287-1152 
Issue Date
2017
Keywords
Adenovirus ; Cicatrix ; Gene therapy ; Relaxin
Abstract
Background : Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. Methods : Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. Results : Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. Conclusion : Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated.
Files in This Item:
T201702074.pdf Download
DOI
10.7181/acfs.2017.18.1.9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Cancer Research (암연구소) > 1. Journal Papers
Yonsei Authors
김용욱(Kim, Yong Oock) ORCID logo https://orcid.org/0000-0002-3756-4809
나동균(Rah, Dong Kyun)
윤인식(Yun, In Sik) ORCID logo https://orcid.org/0000-0003-1103-7047
윤채옥(Yun, Chae Ok)
이원재(Lee, Won Jai) ORCID logo https://orcid.org/0000-0003-3056-0503
정복기(Jung, Bok Ki) ORCID logo https://orcid.org/0000-0002-4347-560X
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154288
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse