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Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study
DC Field | Value | Language |
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dc.contributor.author | 김용욱 | - |
dc.contributor.author | 나동균 | - |
dc.contributor.author | 윤인식 | - |
dc.contributor.author | 이원재 | - |
dc.contributor.author | 정복기 | - |
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2017-11-02T08:16:48Z | - |
dc.date.available | 2017-11-02T08:16:48Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2287-1152 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154288 | - |
dc.description.abstract | Background : Relaxin is a transforming growth factor β1 antagonist. To determine the effects of relaxin on scar reduction, we investigated the scar remodeling process by injecting relaxin-expressing adenoviruses using a pig scar model. Methods : Scars with full thickness were generated on the backs of Yorkshire pigs. Scars were divided into two groups (relaxin [RLX] and Control). Adenoviruses were injected into the RLX (expressing relaxin) and Control (not expressing relaxin) groups. Changes in the surface areas, color index and pliability of scars were compared. Results : Fifty days after treatment, the surface areas of scars decreased, the color of scars was normalized, and the pliability of scars increased in RLX group. Conclusion : Relaxin-expressing adenoviruses improved the surface area, color, and pliability of scars. The mechanism of therapeutic effects on scar formation should be further investigated. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Korean Cleft Palate-Craniofacial Association | - |
dc.relation.isPartOf | Archives of Craniofacial Surgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of Relaxin Expressing Adenovirus on Scar Remodeling: A Preliminary Study | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Plastic Surgery & Reconstructive Surgery | - |
dc.contributor.googleauthor | Bok Ki Jung | - |
dc.contributor.googleauthor | Won Jai Lee | - |
dc.contributor.googleauthor | Eunhye Kang | - |
dc.contributor.googleauthor | Hyo Min Ahn | - |
dc.contributor.googleauthor | Yong Oock Kim | - |
dc.contributor.googleauthor | Dong Kyun Rah | - |
dc.contributor.googleauthor | Chae-Ok Yun | - |
dc.contributor.googleauthor | In Sik Yun | - |
dc.identifier.doi | 10.7181/acfs.2017.18.1.9 | - |
dc.contributor.localId | A01229 | - |
dc.contributor.localId | A02588 | - |
dc.contributor.localId | A03005 | - |
dc.contributor.localId | A04665 | - |
dc.contributor.localId | A02614 | - |
dc.contributor.localId | A00749 | - |
dc.relation.journalcode | J00212 | - |
dc.relation.journalsince | 2012~ | - |
dc.relation.journalbefore | ~2011 Journal of the Korean Cleft Palate-Craniofacial Association (대한두개안면성형외과학회지) | - |
dc.subject.keyword | Adenovirus | - |
dc.subject.keyword | Cicatrix | - |
dc.subject.keyword | Gene therapy | - |
dc.subject.keyword | Relaxin | - |
dc.contributor.alternativeName | Kim, Yong Oock | - |
dc.contributor.alternativeName | Rah, Dong Kyun | - |
dc.contributor.alternativeName | Yun, In Sik | - |
dc.contributor.alternativeName | Lee, Won Jai | - |
dc.contributor.alternativeName | Jung, Bok Ki | - |
dc.contributor.alternativeName | Yun, Chae Ok | - |
dc.contributor.affiliatedAuthor | Rah, Dong Kyun | - |
dc.contributor.affiliatedAuthor | Yun, In Sik | - |
dc.contributor.affiliatedAuthor | Lee, Won Jai | - |
dc.contributor.affiliatedAuthor | Jung, Bok Ki | - |
dc.contributor.affiliatedAuthor | Yun, Chae Ok | - |
dc.contributor.affiliatedAuthor | Kim, Yong Oock | - |
dc.citation.title | Archives of Craniofacial Surgery | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 15 | - |
dc.identifier.bibliographicCitation | Archives of Craniofacial Surgery, Vol.18(1) : 9-15, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42255 | - |
dc.type.rims | ART | - |
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