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Predicting lymph node metastasis in patients with papillary thyroid carcinoma by vascular index on power Doppler ultrasound

Authors
 Ji Hye Lee  ;  Hyun Joo Shin  ;  Jung Hyun Yoon  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Hye Sun Lee  ;  Hyeong Ju Kwon  ;  Jin Young Kwak 
Citation
 Head & Neck, Vol.39(2) : 334-340, 2017 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2017
MeSH
Adult ; Biomarkers/blood ; Carcinoma, Papillary/blood supply ; Carcinoma, Papillary/mortality ; Carcinoma, Papillary/surgery* ; Cohort Studies ; Female ; Humans ; Lymph Nodes/pathology* ; Lymphatic Metastasis ; Male ; Middle Aged ; Neovascularization, Pathologic/diagnostic imaging* ; Predictive Value of Tests ; Preoperative Care/methods ; Prognosis ; Prospective Studies ; Survival Analysis ; Thyroid Neoplasms/blood supply ; Thyroid Neoplasms/mortality ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/surgery* ; Ultrasonography, Doppler ; Vascular Endothelial Growth Factor A/blood*
Keywords
lymph node metastasis ; microvessel density ; papillary thyroid carcinoma ; vascular endothelial growth factor ; vascular index
Abstract
BACKGROUND: For patients with papillary thyroid carcinoma (PTC), lymph node metastasis is associated with an increased recurrence rate. The purpose of this study was to investigate whether the vascular endothelial growth factor (VEGF), microvessel density (MVD), and vascular index (VI) can predict lymph node metastasis in patients with PTC. METHODS: From January 2011 to October 2011, 202 patients with PTCs underwent preoperative staging ultrasound evaluation. To evaluate vascularity, we measured the VI, VEGF expression, and MVD. RESULTS: The VI was significantly correlated with MVD (p = .009). On multivariate analysis, young age showed a significant correlation with lymph node metastasis (p < .001; p < .001; p < .001). However, the other clinicopathologic features, VEGF, MVD, and VI failed to show any significant correlations with lymph node metastasis. CONCLUSION: Although the VI showed significant correlation with MVD, it was not significantly correlated to lymph node metastasis. © 2016 Wiley Periodicals, Inc. Head Neck 39: 334-340, 2017.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.24592/abstract
DOI
10.1002/hed.24592
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
곽진영(Kwak, Jin Young) ORCID logo https://orcid.org/0000-0002-6212-1495
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
신현주(Shin, Hyun Joo) ORCID logo https://orcid.org/0000-0002-7462-2609
윤정현(Yoon, Jung Hyun) ORCID logo https://orcid.org/0000-0002-2100-3513
이지혜(Lee, Ji Hye) ORCID logo https://orcid.org/0000-0002-1501-9105
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154123
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