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Fine-needle aspiration versus core needle biopsy for diagnosis of thyroid malignancy and neoplasm: a matched cohort study

Authors
 Soo-Yeon Kim  ;  Hye Sun Lee  ;  Jieun Moon  ;  Eun-Kyung Kim  ;  Hee Jung Moon  ;  Jung Hyun Yoon  ;  Jin Young Kwak 
Citation
 European Radiology, Vol.27(2) : 801-811, 2017 
Journal Title
 European Radiology 
ISSN
 0938-7994 
Issue Date
2017
MeSH
Adenocarcinoma, Follicular/diagnostic imaging ; Adenocarcinoma, Follicular/pathology* ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biopsy, Fine-Needle* ; Biopsy, Large-Core Needle* ; Biopsy, Needle ; Carcinoma, Papillary/diagnostic imaging ; Carcinoma, Papillary/pathology* ; Child ; Cohort Studies ; Female ; Humans ; Image-Guided Biopsy* ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies ; Sensitivity and Specificity ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/pathology* ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/pathology* ; Tumor Burden ; Ultrasonography ; Young Adult
Keywords
Core needle biopsy ; Fine needle aspiration ; Malignancy ; Neoplasm ; Thyroid
Abstract
OBJECTIVES: To compare the diagnostic performances of fine-needle aspiration (FNA) and core needle biopsy (CNB) in the diagnosis of thyroid malignancy and neoplasm in patients who underwent surgery for thyroid nodules. METHODS: This retrospective study was approved by the institutional review board, and the need to obtain informed consent was waived. 3192 patients who underwent FNA (n = 3048) or CNB (n = 144) for diagnosis of thyroid nodules and then proceeded with surgery were included. Surgical pathologic diagnosis was the reference standard. Diagnostic performances of FNA and CNB to predict malignancy and neoplasm were compared. Propensity score matching was used to match patients with FNA with those with CNB because there were significant differences in the number of nodules and nodule characteristics between the FNA and CNB groups. RESULTS: Before matching, the sensitivity and accuracy of FNA were significantly higher or comparable with those of CNB, and the specificity, negative predictive value and positive predictive value were comparable. After matching, the diagnostic performances were similar, with the exception of specificity for predicting neoplasm being higher with CNB than with FNA. CONCLUSION: FNA showed comparable diagnostic performance to CNB; therefore, there may be no benefit in performing CNB to diagnose papillary thyroid carcinoma and neoplasm. KEY POINTS: • Diagnostic performances of FNA and CNB for thyroid malignancy and neoplasm were compared. • FNA showed comparable performances to CNB both before and after statistical matching. • There may be no benefit in performing CNB, given the comparable performances.
Full Text
https://link.springer.com/article/10.1007%2Fs00330-016-4424-1
DOI
10.1007/s00330-016-4424-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
곽진영(Kwak, Jin Young) ORCID logo https://orcid.org/0000-0002-6212-1495
김은경(Kim, Eun-Kyung) ORCID logo https://orcid.org/0000-0002-3368-5013
문희정(Moon, Hee Jung) ORCID logo https://orcid.org/0000-0002-5643-5885
윤정현(Yoon, Jung Hyun) ORCID logo https://orcid.org/0000-0002-2100-3513
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154053
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