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Comparative Gene-Expression Analysis of Periodontal Ligament and Dental Pulp in the Human Permanent Teeth

Other Titles
 사람 영구치에서 치주인대 및 치수 조직의 유전자 발현에 대한 비교 연구 
Authors
 Suk Woo Lee  ;  Mijeong Jeon  ;  Hyo-Seol Lee  ;  Je Seon Song  ;  Heung-Kyu Son  ;  Hyung-Jun Choi  ;  Han-Sung Jung  ;  Seok-Jun Moon  ;  Wonse Park  ;  Seong-Oh Ki 
Citation
 Journal of the Korean Academy of Pediatric Dentistry (대한소아치과학회지), Vol.43(2) : 166-175, 2016 
Journal Title
 Journal of the Korean Academy of Pediatric Dentistry (대한소아치과학회지) 
ISSN
 1226-8496 
Issue Date
2016
Abstract
There is no genetic activity information with the functions of dental pulp and periodontal ligament in human. The purpose of this study was to identify the gene-expression profiles of, and the molecular biological differences between periodontal ligament and dental pulp obtained from human permanent teeth. cDNA microarray analysis identified 347 genes with a fourfold or greater difference in expression level between the two tissue types 83 and 264, of which were more plentiful in periodontal ligament and dental pulp, respectively. Periodontal ligament exhibited strong expression of genes related to collagen synthesis (FAP), collagen degradation ( MMP3, MMP9, and MMP13), and bone development and remodeling ( SSP1, BMP3, ACP5, CTSK, and PTHLH). Pulp exhibited strong expression of genes associated with calcium ions ( CALB1, SCIN, and CDH12) and the mineralization and formation of enamel and dentin ( SPARC/SPOCK3, PHEX, AMBN, and DSPP). Among these genes, SPP1, SPARC/SPOCK3, AMBN, and DSPP were well known in dental research. However, the other genes are the newly found and it may help to find a good source of regenerative therapy if further study is performed. Comparative Gene-Expression Analysis of Periodontal Ligament and Dental Pulp in the Human Permanent Teeth (PDF Download Available). Available from: https://www.researchgate.net/publication/305515699_Comparative_Gene-Expression_Analysis_of_Periodontal_Ligament_and_Dental_Pulp_in_the_Human_Permanent_Teeth [accessed Jul 27, 2017].
Files in This Item:
T201606072.pdf Download
DOI
10.5933/JKAPD.2016.43.2.166
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
Yonsei Authors
Kim, Seong Oh(김성오) ORCID logo https://orcid.org/0000-0002-8620-1377
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Son, Heung Kyu(손흥규)
Song, Je Seon(송제선) ORCID logo https://orcid.org/0000-0001-8620-5629
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
Choi, Hyung Jun(최형준) ORCID logo https://orcid.org/0000-0002-3315-6912
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153085
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