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Prediction of biochemical recurrence after radical prostatectomy with PI-RADS version 2 in prostate cancers: initial results

 Sung Yoon Park  ;  Young Taik Oh  ;  Dae Chul Jung  ;  Nam Hoon Cho  ;  Young Deuk Choi  ;  Koon Ho Rha  ;  Sung Joon Hong 
 EUROPEAN RADIOLOGY, Vol.26(8) : 2502-2509, 2016 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Humans ; Kaplan-Meier Estimate ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local*/metabolism ; Neoplasm Recurrence, Local*/pathology ; Predictive Value of Tests ; Proportional Hazards Models ; Prostate-Specific Antigen/analysis* ; Prostatectomy/methods ; Prostatic Neoplasms/diagnostic imaging* ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Retrospective Studies
Biochemical recurrence ; MRI ; PI-RADS ; Prostate cancer ; Radical prostatectomy
OBJECTIVES: To determine whether the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) helps predict biochemical recurrence (BCR) after radical prostatectomy for prostate cancer (PCa). METHODS: We included 158 patients with PCa who underwent magnetic resonance imaging (MRI) and radical prostatectomy (RP). Clinical (prostate-specific antigen, greatest percentage of core, and percentage of positive core number), PI-RADSv2 score on MRI, and surgical parameters (Gleason score, extracapsular extension, seminal vesicle invasion, and tumour volume) were investigated. Univariate and multivariate analyses using Cox's proportional hazards model were performed to assess parameters predictive of BCR (two consecutive prostate specific antigens ≥0.2 ng/ml). Kaplan-Meier survival curves were analyzed. RESULTS: The rate of BCR was 13.3 % (21/158) after surgery (median follow-up, 25 months; range, 12-36). No subject with a PI-RADS score <4 had BCR. In univariate analysis, all parameters were significant for BCR (p?<?0.05), except seminal vesicle invasion (p?=?0.254). Meanwhile, PI-RADS score was the only independent parameter for BCR in multivariate analysis (p?<?0.05). Two-year, BCR-free survival post-RP was significantly lower for PI-RADS ≥4 (84.7-85.5 %) than for PI-RADS <4 (100 %; p?<?0.05). CONCLUSION: As a preoperative imaging tool, PI-RADSv2 may be useful to predict BCR after radical prostatectomy for PCa. POINTS: ? No subject with PI-RADS <4 had BCR after RP ? PI-RADSv2 was the only predictor of BCR in multivariate analysis ? Two-year, BCR-free survival following RP was lower for PI-RADS≥4 than for PI-RADS<4 ? Inter-rater agreement was good for PI-RADS ≥4 or not.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Park, Sung Yoon(박성윤)
Oh, Young Taik(오영택) ORCID logo https://orcid.org/0000-0002-4438-8890
Jung, Dae Chul(정대철) ORCID logo https://orcid.org/0000-0001-5769-5083
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
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