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Prediction of biochemical recurrence after radical prostatectomy with PI-RADS version 2 in prostate cancers: initial results

Authors
 Sung Yoon Park  ;  Young Taik Oh  ;  Dae Chul Jung  ;  Nam Hoon Cho  ;  Young Deuk Choi  ;  Koon Ho Rha  ;  Sung Joon Hong 
Citation
 European Radiology, Vol.26(8) : 2502-2509, 2016 
Journal Title
 European Radiology 
ISSN
 0938-7994 
Issue Date
2016
MeSH
Aged ; Aged, 80 and over ; Humans ; Kaplan-Meier Estimate ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local*/metabolism ; Neoplasm Recurrence, Local*/pathology ; Predictive Value of Tests ; Proportional Hazards Models ; Prostate-Specific Antigen/analysis* ; Prostatectomy/methods ; Prostatic Neoplasms/diagnostic imaging* ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Retrospective Studies
Keywords
Biochemical recurrence ; MRI ; PI-RADS ; Prostate cancer ; Radical prostatectomy
Abstract
OBJECTIVES: To determine whether the Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) helps predict biochemical recurrence (BCR) after radical prostatectomy for prostate cancer (PCa). METHODS: We included 158 patients with PCa who underwent magnetic resonance imaging (MRI) and radical prostatectomy (RP). Clinical (prostate-specific antigen, greatest percentage of core, and percentage of positive core number), PI-RADSv2 score on MRI, and surgical parameters (Gleason score, extracapsular extension, seminal vesicle invasion, and tumour volume) were investigated. Univariate and multivariate analyses using Cox's proportional hazards model were performed to assess parameters predictive of BCR (two consecutive prostate specific antigens ≥0.2 ng/ml). Kaplan-Meier survival curves were analyzed. RESULTS: The rate of BCR was 13.3 % (21/158) after surgery (median follow-up, 25 months; range, 12-36). No subject with a PI-RADS score <4 had BCR. In univariate analysis, all parameters were significant for BCR (p?<?0.05), except seminal vesicle invasion (p?=?0.254). Meanwhile, PI-RADS score was the only independent parameter for BCR in multivariate analysis (p?<?0.05). Two-year, BCR-free survival post-RP was significantly lower for PI-RADS ≥4 (84.7-85.5 %) than for PI-RADS <4 (100 %; p?<?0.05). CONCLUSION: As a preoperative imaging tool, PI-RADSv2 may be useful to predict BCR after radical prostatectomy for PCa. POINTS: ? No subject with PI-RADS <4 had BCR after RP ? PI-RADSv2 was the only predictor of BCR in multivariate analysis ? Two-year, BCR-free survival following RP was lower for PI-RADS≥4 than for PI-RADS<4 ? Inter-rater agreement was good for PI-RADS ≥4 or not.
Full Text
http://link.springer.com/article/10.1007%2Fs00330-015-4077-5
DOI
10.1007/s00330-015-4077-5
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
나군호(Rha, Koon Ho) ORCID logo https://orcid.org/0000-0001-8588-7584
박성윤(Park, Sung Yoon)
오영택(Oh, Young Taik) ORCID logo https://orcid.org/0000-0002-4438-8890
정대철(Jung, Dae Chul) ORCID logo https://orcid.org/0000-0001-5769-5083
조남훈(Cho, Nam Hoon) ORCID logo https://orcid.org/0000-0002-0045-6441
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
홍성준(Hong, Sung Joon) ORCID logo https://orcid.org/0000-0001-9869-065X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151807
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