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Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling

Authors
 Juhyun Song  ;  Byeori Lee  ;  Somang Kang  ;  Yumi Oh  ;  Eosu Kim  ;  Chul-Hoon Kim  ;  Ho-Taek Song  ;  Jong Eun Lee 
Citation
 Experimental Neurobiology, Vol.25(1) : 24-32, 2016 
Journal Title
 Experimental Neurobiology 
ISSN
 1226-2560 
Issue Date
2016
Keywords
Agmatine ; Cell death ; High glucose ; Hyperglycemia ; Pro-inflammatory cytokines ; Senescence ; p21 ; p53
Abstract
Neuronal senescence caused by diabetic neuropathy is considered a common complication of diabetes mellitus. Neuronal senescence leads to the secretion of pro-inflammatory cytokines, the production of reactive oxygen species, and the alteration of cellular homeostasis. Agmatine, which is biosynthesized by arginine decarboxylation, has been reported in previous in vitro to exert a protective effect against various stresses. In present study, agmatine attenuated the cell death and the expression of pro-inflammatory cytokines such as IL-6, TNF-alpha and CCL2 in high glucose in vitro conditions. Moreover, the senescence associated-β-galatosidase's activity in high glucose exposed neuronal cells was reduced by agmatine. Increased p21 and reduced p53 in high glucose conditioned cells were changed by agmatine. Ultimately, agmatine inhibits the neuronal cell senescence through the activation of p53 and the inhibition of p21. Here, we propose that agmatine may ameliorate neuronal cell senescence in hyperglycemia.
DOI
10.5607/en.2016.25.1.24
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김어수(Kim, Eosu) ORCID logo https://orcid.org/0000-0001-9472-9465
김철훈(Kim, Chul Hoon) ORCID logo https://orcid.org/0000-0002-7360-429X
송주현(Song, Ju Hyun)
송호택(Song, Ho Taek) ORCID logo https://orcid.org/0000-0002-6655-2575
이벼리(Lee, Byeori)
이종은(Lee, Jong Eun) ORCID logo https://orcid.org/0000-0001-6203-7413
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151691
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