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Differential Antiproliferative Responses of Green Tea Polyphenol for Fibroblast Cell Line versus Normal Fibroblast

Authors
 Dong-Wook Han  ;  Hak Hee Kim  ;  Mi Hee Lee  ;  Hyun Joo Son  ;  Hyun Sook Baek  ;  Hyun Jeong Kim  ;  Jong-Chul Park 
Citation
 Biomaterials Research (생체재료학회지), Vol.9(4) : 188-192, 2005 
Journal Title
 Biomaterials Research (생체재료학회지) 
ISSN
 1226-4601 
Issue Date
2005
MeSH
Antiproliferative activity ; Green tea polyphenols ; Fibroblast cell line ; Normal fibroblasts ; Cell cycle arrest
Keywords
Antiproliferative activity ; Green tea polyphenols ; Fibroblast cell line ; Normal fibroblasts ; Cell cycle arrest
Abstract
The polyphenolic compounds present in green tea show antimutagenic, anti-inflammatory and antitumorigenic effects in many cell culture systems and animal tumor models. Epidemiologic studies have also suggested that green tea consumption might be effective in the prevention of certain human cancers. In this study, the differential antiproliferative responses of green tea polyphenols (GTP) were investigated in fibroblast cell line (L-929 cells, from mouse connective tissue) and normal fibroblasts (from neonatal human dermis). GTP treatment (100 μM for 24 h) resulted in significant (p < 0.05) inhibition of cell proliferation and morphological alterations with decreased local attachment, but not in normal fibroblasts. Cell cycle analysis revealed that the GTP treatment resulted in an appreciable G0/G1-phase arrest of the cell cycle in L-929 cells at 100 μM concentration, while under similar experimental conditions, no evidence of G0/G1-phase cell cycle arrest was found in normal fibroblasts at the same dose. These results suggest that antiproliferative activity of GTP may be attributed to the differential regulation of cell cycle in fibroblast cell line and normal fibroblasts, which GTP may be exploited to craft strategies for the chemoprevention and/or therapy against cancer by GTP.
Files in This Item:
T200501492.pdf Download
DOI
OAK-2005-06389
Appears in Collections:
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hak Hee(김학희)
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
Baek, Hyun Sook(백현숙)
Son, Hyun Joo(손현주)
Lee, Mi Hee(이미희) ORCID logo https://orcid.org/0000-0002-9630-7044
Han, Dong Wook(한동욱)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151478
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