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Differential Antiproliferative Responses of Green Tea Polyphenol for Fibroblast Cell Line versus Normal Fibroblast
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김학희 | - |
dc.contributor.author | 박종철 | - |
dc.contributor.author | 백현숙 | - |
dc.contributor.author | 손현주 | - |
dc.contributor.author | 한동욱 | - |
dc.contributor.author | 이미희 | - |
dc.date.accessioned | 2017-10-26T06:54:35Z | - |
dc.date.available | 2017-10-26T06:54:35Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1226-4601 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151478 | - |
dc.description.abstract | The polyphenolic compounds present in green tea show antimutagenic, anti-inflammatory and antitumorigenic effects in many cell culture systems and animal tumor models. Epidemiologic studies have also suggested that green tea consumption might be effective in the prevention of certain human cancers. In this study, the differential antiproliferative responses of green tea polyphenols (GTP) were investigated in fibroblast cell line (L-929 cells, from mouse connective tissue) and normal fibroblasts (from neonatal human dermis). GTP treatment (100 μM for 24 h) resulted in significant (p < 0.05) inhibition of cell proliferation and morphological alterations with decreased local attachment, but not in normal fibroblasts. Cell cycle analysis revealed that the GTP treatment resulted in an appreciable G0/G1-phase arrest of the cell cycle in L-929 cells at 100 μM concentration, while under similar experimental conditions, no evidence of G0/G1-phase cell cycle arrest was found in normal fibroblasts at the same dose. These results suggest that antiproliferative activity of GTP may be attributed to the differential regulation of cell cycle in fibroblast cell line and normal fibroblasts, which GTP may be exploited to craft strategies for the chemoprevention and/or therapy against cancer by GTP. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.publisher | 한국 생체재료 학회 | - |
dc.relation.isPartOf | Biomaterials Research (생체재료학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antiproliferative activity | - |
dc.subject.MESH | Green tea polyphenols | - |
dc.subject.MESH | Fibroblast cell line | - |
dc.subject.MESH | Normal fibroblasts | - |
dc.subject.MESH | Cell cycle arrest | - |
dc.title | Differential Antiproliferative Responses of Green Tea Polyphenol for Fibroblast Cell Line versus Normal Fibroblast | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | Others | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.department | Severance Hospital (세브란스병원) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학교실) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Dong-Wook Han | - |
dc.contributor.googleauthor | Hak Hee Kim | - |
dc.contributor.googleauthor | Mi Hee Lee | - |
dc.contributor.googleauthor | Hyun Joo Son | - |
dc.contributor.googleauthor | Hyun Sook Baek | - |
dc.contributor.googleauthor | Hyun Jeong Kim | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.identifier.doi | OAK-2005-06389 | - |
dc.contributor.localId | A01095 | - |
dc.contributor.localId | A01662 | - |
dc.contributor.localId | A01843 | - |
dc.contributor.localId | A02001 | - |
dc.contributor.localId | A04861 | - |
dc.contributor.localId | A04275 | - |
dc.relation.journalcode | J00314 | - |
dc.relation.journalsince | 1997~2013 | - |
dc.relation.journalafter | 2014~ Biomaterials Research | - |
dc.subject.keyword | Antiproliferative activity | - |
dc.subject.keyword | Green tea polyphenols | - |
dc.subject.keyword | Fibroblast cell line | - |
dc.subject.keyword | Normal fibroblasts | - |
dc.subject.keyword | Cell cycle arrest | - |
dc.contributor.alternativeName | Kim, Hak Hee | - |
dc.contributor.alternativeName | Kim, Hak Hee | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.alternativeName | Baek, Hyun Sook | - |
dc.contributor.alternativeName | Son, Hyun Joo | - |
dc.contributor.alternativeName | Lee, Mi Hee | - |
dc.contributor.alternativeName | Han, Dong Wook | - |
dc.contributor.affiliatedAuthor | 김학희 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 188 | - |
dc.citation.endPage | 192 | - |
dc.identifier.bibliographicCitation | Biomaterials Research (생체재료학회지), Vol.9(4) : 188-192, 2005 | - |
dc.date.modified | 2017-05-04 | - |
dc.identifier.rimsid | 44634 | - |
dc.type.rims | ART | - |
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